Principal Investigator
Linden Hu
Associate Professor
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Program Affiliations
Immunology
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-8498
Lab (617) 636-7613
Fax (617) 636-3216
Send Email |
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Selected Publications
Behera, A. K., Hildebrand, W.,
Szafranski, J., Hung, H. H., Grodzinsky, A. J., Lafyatis,
R., Koch, A. E., Kalish, R. Perides, G., Steere,
A. C., and Hu, L. T. 2006. Role of aggrecanase-1
in Lyme arthritis. Arthr. Rheum. 54: 3319-3329.
[Abstract]
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Behera, A. K., Hildebrand, E.,
Uematsu, S., Akira, S., Coburn, J., and Hu, L. T.
2006. Identification of a TLR-independent pathway
for Borrelia burgdorferi-induced expression of matrix
metalloproteinases and inflammatory mediators through
binding to integrin α3β1. J. Immunol.
177: 657-664.
[Abstract]
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Behera, A. K., Hildebrand, E.,
Bronson, R. T., Perides, G., Uematsu, S., Akira,
S., and Hu, L. T. 2006. MyD88 deficiency results
in tissue-specific changes in cytokine induction
and inflammation in interleukin-18-independent mice
infected with Borrelia burgdorferi. Infect. Immun.
74: 1462-1470.
[Abstract]
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Scheckelhoff, M. R., Telford,
S. R., and Hu, L. T. 2006. Protective efficacy of
an oral vaccine to reduce carriage of Borrelia burgdorferi
(strain N40) in mouse and tick reservoirs. Vaccine
24: 1949-1947.
[Abstract]
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Behera, A. K., Hildebrand, E.,
Scagliotti, J., Steere, A. C., and Hu, L. T. 2005.
Induction of host matrix metalloproteinases by Borrelia
burgdorferi differs in human and murine lyme arthritis.
Infect. Immun. 73: 126-134.
[Abstract]
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Ross, J. J. and Hu, L. T. 2004.
Bacterial and Lyme arthritis. Curr. Inf. Dis. Rep.
6:380-387.
[Abstract]
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Behera, A. K., Thorpe, C. M.,
Kidder, J. M, Smith, W., Hildebrand, E., and Hu,
L. T. 2004. Borrelia burgdorferi-induced expression
of matrix matalloproteinases from human cnondrocytes
requires mitogen-activated protein kinase and Janus
kinase/signal transducer and activator of transcription
signaling pathways. Infect. Immun. 72: 2864-2861.
[Abstract]
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Wang, X.G., Scagliotti, J.M.,
and L.T. Hu. 2004. Phospholipid synthesis in Borrelia
burgdorferi: BB0249 and BB0721 encode functional
phosphatidylcholine synthase and phosphatidylglycerolphosphate
synthase proteins Microbiology 150: 391-397.
[Abstract]
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Wang, X. G., Kidder, J. M., Scagliotti,
J. P., Klempner, M. S., Noring, R., and Hu, L. T. 2004.
Analysis of differences in the functional properties
of five related oligopeptide permease A (OppA) proteins
of Borrelia burgdorferi. J. Bacteriol. 186: 51-60.
[Abstract]
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Hatch, S. and Hu, L. T. 2004. Lyme
Disease. In Preventing Occupational Disease and Injury,
K. Rest, G. Wagner, G., J. Weeks, and Levy, B. S. Eds.
Second Edition, American Public Health Association
In press.
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Ross, J. R. and Hu, L. T. 2003.
Septic arthritis of the pubic symphysis: a review of
100 cases, Medicine 82: 340-345.
[Abstract]
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Kaplan, R. F., Trevino, R. P.,
Johnson, G. M., Levy, L., Dornbush,R. L., Hu, L. T.,
Evans, J., Weinstein, A., Schmid, C. H. and Klempner,
M. S.. 2003. Cognitive functioning in post-treatment
Lyme disease. Neurol. 60: 1916-1922.
[Abstract]
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Wang, X. G., Lin, B. Kidder, J.
M., Telford, S., and Hu, L. T. 2002. Effects of environmental
changes on expression of the opp genes of Borrelia
burgdorferi. J. Bacteriol. 184: 6198-6206.
[Abstract]
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McDowell, J. V., Sung, S. Y., Hu,
L. T., and Marconi, R. T. 2002. Evidence that the variable
regions of the central domain of VlsE are antigenic
during infection with Lyme disease spirochetes. Infect.
Immun. 70: 4196-4203.
[Abstract]
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Klempner, M.S., Hu, L. T., Evans,
J., Schmid, C.H., Johnson, G., Trevino, R., Norton,
L., Levy, L., Wall, D. McCall, J. Kosinski, M. and
Weinstein, A. 2001. Two controlled trials of antibiotic
treatment in patients with persistent symptoms and
a history of Lyme disease. New Engl. J. Med. 345: 85-92.
[Abstract]
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Klempner, M. S., Schmid, C., Hu,
L. T., Steere, A. C., Aguero-Rosenfeld, M. E., Wilson,
M., Johnson G., McCloud, B., Noring, R., and Weinstein,
A. 2001. Intralaboratory reliability of serologic and
urine testing for Lyme disease. Am. J. Med. 110: 217-219.
[Abstract]
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Lin, B., Short, S. A., Eskildsen,
M., Klempner, M. A., and Hu, L. T. 2001. Functional
testing of putative oligopeptide permease (Opp) proteins
Borrelia burgdorferi: a complementation model in opp-
Escherichia coli. Biochim. Biophys. Acta 1499:222-231.
[Abstract]
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Hu, L. T., Eskildsen, M. A., Masgala,
C., Steere, A. C., Arner, E. C., Pratta, M. A., Grodzinsky,
A. J., Loening, A. and Perides, G. 2001. Host metalloproteinases
in Lyme arthritis. Arthr. Rheum. 44: 1401-4110.
[Abstract]
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Lin, B, Kidder, J. M., Noring, R.,
Steere, A. C., Klempner, M. S., and Hu, L. T. 2001.
Differences in synovial fluid levels of matrix metalloproteinases
suggest separate mechanisms of pathogenesis in pre
and post antibiotic treated Lyme arthritis. J. Infect.
Dis. 182: 174-180.
[Abstract]
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Hu, L. T. and Klempner. M. S. 2001.
Update on the diagnosis and treatment of Lyme disease.
Ann. Rev. Int. Med. 46: 247-275.
[Abstract]
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Lin, B., Noring, R., Steere, A.,
Klempner, M. S., and Hu, L. T. 2000. Soluble CD14 levels
in the serum, synovial fluid and cerebrospinal fluid
of patients with various stages of Lyme disease, J.
Infect. Dis.181: 1185-1188.
[Abstract]
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Hu, L. T. and Klempner, M. S. 1997.
Lyme Disease. In Infectious Diseases and Antimicrobial
Therapy of the Ears, Nose and Throat. V.L. Yu and J.T.
Johnson, Eds.,W. B. Saunders Co., Philadelphia, pp.
533-542.
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Hu, L. T., Perides, G., Tanner,
L. M., and Klempner, M. S. 1997. Detection of a 130kDa
matrix metalloproteinase in cerebrospinal fluid in
a patient with Lyme neuroborreliosis, Clin. Infect.
Dis. 24: 1276-1277.
[Abstract]
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Hu, L. T. and Klempner, M. S. 1997.
Host-pathogen interactions in the immunopathogenesis
of Lyme disease. J. Clin. Immunol. 17: 354-365.
[Abstract]
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Hu, L. T., Pratt, S. D., Perides,
G., Katz, L., Rogers, R. A., and Klempner, M. S. 1997.
Isolation, cloning and expression of a 70 kDa plasminogen
binding protein of Borrelia burgdorferi. Infect. Immun.
65: 4989-4995.
[Abstract]
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