Analysis of Bacterial Uptake & Growth within Mammalian Cells
Isberg Laboratory


Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111

Lab (617) 636-4092
   

Aisling Dugan
Postdoctoral Fellow
Ph.D. Brown University, 2007
B.A. Smith College, 2000

Thesis
The Interactions Between BK Virus and Host Cell Receptors

Current Research
I am dissecting the role of host cell kinases and phosphatases in Legionella pneumophila infection.

Publications

  1. Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick V, Isberg RR. 2009. The Amoebal MAP Kinase Response to Legionella pneumophila Is Regulated by DupA. Cell Host & Microbe. 6(3): 253-67.
  2. Gasparovic ML, Maginnis MS, O'Hara BA, Dugan AS, Atwood WJ. 2009. Modulation of PML protein expression regulates JCV infection. Virology. 390(2):279-88.
  3. Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O’Hara BA, Atwood WJ. 2008. Human alpha-defensins Inhibit BK Virus by Aggregating Virions and Blocking Binding to Host Cells. J Biol Chem. 283(45): 31125-32.
  4. Dugan AS, Gasparovic ML, Atwood WJ. 2008. Direct Correlation between Sialic Acid Binding and Infection of Cells by Two Human Polyomaviruses (JCV and BKV). J Virol. 82(5): 2560-4.
  5. Dugan AS, Gasparovic ML, Tsomaia N, Mierke DF, O’Hara BA, Manley K, Atwood WJ. 2007. Identification of amino acid residues in BK virus VP1 that are critical for viability and growth. J Virol. 81(21): 11798-808.
  6. Dugan AS, Eash S, Atwood WJ. 2006. Update on BK Virus Entry and Intracellular Trafficking. Transpl Infect Dis. 8(2): 62-7.
  7. Gee GV, Dugan AS, Tsomaia N, Meirke DF, Atwood WJ. 2006. The Role of Sialic Acid in Human Polyomavirus Infections. Glycoconj J. 23(1-2): 19-26.
  8. Lipscomb EA, Simpson KJ, Lyle SR, Ring JE, Dugan AS, Mercurio AM. 2005. The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res. 65(23): 10970-6.
  9. Dugan AS, Eash S, Atwood W. 2005. An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus. J Virol. 79(22): 14442-5.
  10. Elphick GF, Querbes W, Jordan JA, Gee GV, Eash S, Manley K, Dugan A, Stanifer M, Bhatnagar A,  Kroeze W,  Roth BL, and Atwood WJ. 2004. The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells. Science. 306(5700): 1380-3.