Analysis of Bacterial Uptake & Growth within Mammalian Cells

Alexander Ensminger
Postdoctoral Fellow
Ph.D. Massachusetts Institute of Technology, 2006
B.S. Haverford College, 1999

Thesis
Autosomal random asynchronous replication is analogous to X-chromosome inactivation.

Current Research
I am investigating how Legionella pneumophila co-opts eukaryotic pathways to establish an intracellular replicative niche in host cells.

Publications

1. Hutchinson, J. N., Ensminger, A. W*.*, Clemson, C. M., Lynch, C. R., Lawrence, J.B., and Chess, A. (2007). A screen for nuclear transcripts identifies two linked noncoding RNAs associated with mammalian SC35 domains. BMC Genomics 8, 39. (*co-first author manuscript.)
2. Gimelbrant, A. A., Ensminger, A. W., Qi, P., Zucker, J., and Chess, A. (2005). Monoallelic expression and asynchronous replication of p120 catenin in mouse and human cells. J Biol Chem 280, 1354-1359.
3. Ensminger, A. W., and Chess, A. (2004). Bidirectional promoters regulate the monoallelically expressed Ly49 NK receptors. Immunity 21, 2-3. (review)
4. Ensminger, A. W., and Chess, A. (2004). Coordinated replication timing of monoallelically expressed genes along human autosomes. Hum Mol Genet 13, 651-658.
5. Singh, N., Ebrahimi, F. A., Gimelbrant, A. A., Ensminger, A. W., Tackett, M. R., Qi, P., Gribnau, J., and Chess, A. (2003). Coordination of the random asynchronous replication of autosomal loci. Nat Genet 33, 339-341.
6. Yoshihara, M., Ensminger, A. W., and Littleton, J. T. (2001). Neurobiology and the Drosophila genome. Funct Integr Genomics 1, 235-240. (review)