Analysis of Bacterial Uptake & Growth within Mammalian Cells

Elizabeth Creasey
Postdoctoral Fellow
PhD. Imperial College, University of London, UK
BSc. University of Newcastle upon Tyne, UK

Thesis
Protein interactions in the type III secretion system of enteropathogenic Escherichia coli.

Current Research
Pathways of host cell death induction and inhibition during Legionella pneumophila infection.

Publications

1. Creasey, EA, Delahay, RM, Bishop, AA, Shaw, R, Kenny, B, Knutton, S, and Frankel, G (2003) CesT is a bivalent enteropathogenic Escherichia coli chaperone required for translocation of both Tir and Map. Molecular Microbiology 47:209-221
2. Creasey, EA, and Frankel, G (2003) The structure of the enteropathogenic Escherichia coli type III-secretion apparatus. In Microbial Subversion of Host Cells, O'Connor, CD and Smith DGE (eds) Society for General Microbiology Symposium 62. Cambridge, UK: Cambridge University Press 1-15.
3. Creasey, EA, Delahay, RM, and Frankel, G (2003) Yeast two-hybrid system survey of interactions between LEE-encoded proteins of enteropathogenic Escherichia coli. Microbiology 149: 2093-2106
4. Creasey, EA, Friedberg, D, Shaw, RK, Umanski, T, Knutton, S, Rosenshine, I, and Frankel, G (2003) CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB. Microbiology 149: 3639-3647
5. O'Connell, CB, Creasey, EA, Knutton, S, Elliott, S, Crowther, LJ, Luo, W, Albert, MJ, Kaper, JB, Frankel, G, and Donnenberg, MS (2004) SepL, a protein required for enteropathogenic Escherichia coli type III translocation, interacts with secretion component SepD. Molecular Microbiology 52: 1613-1625
6. Crepin, VF, Prasannan, S, Shaw, RK, Wilson, RK, Creasey, E, Abe, CM, Knutton, S, Frankel, G, and Matthews, S (2005) Structural and functional studies of the enteropathogenic escherichia coli type III needle complex protein EscJ. Molecular Microbiology 55:1658-1670
7. Laguna, RK, Creasey, EA, Li, Z, Valtz, N, and Isberg, R (2006) A Legionella pneumonphila-translocated substrate that is required for growth within macrophages and protection from host cell death. PNAS 103: 18745-18750.