Analysis of Bacterial Uptake & Growth within Mammalian Cells

Gregory Crimmins
Postdoctoral Associate
Ph.D. University of Illinois, Urbana/Champaign
B.S. University of California, Berkeley

Thesis
Interaction of Listeria monocytogenes with a Host Cytosolic Surveillance System

Current Research
I am investigating the manipulation of the immune system by Yersinia pseudotuberculosis, including the spatial control of host cell signaling by Y. pseudotuberculosis virulence factors.

Publications

1. Crimmins, G., Schelle, M., Herskovits, A., Ni, P., Meyer-Morse, N, Iavarone, A., Portnoy, D.(2009. Listeria monocytogenes 6-phosphogluconolactonase (pgl) mutants induce increased activation of a host cytosolic surveillance pathway. Infection and Immunity, In Press.
2. Crimmins, G.*, Herskovits, A.*, Rehder, K., Sivick, K., Lauer, P., Dubensky, T., Portnoy, D. 2008. Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity. PNAS, 105 (29), 10191-10196. (*co-first authors)
3. Leber. J., Crimmins, G., Raghavan, S., Meyer-Morse, N., Cox, J., Portnoy, D. 2008. Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen. Public Library of Science - Pathogens, 11; 4(1): e6.
4. Wolfe, A.D., Crimmins, G., Cameron, J.A., Henry, J.J. 2004. Early regeneration genes: Building a molecular profile for shared expression in cornea-lens transdifferentiation and hindlimb regeneration in Xenopus laevis. Jun, Developmental Dynamics, 230 (4), 615-629.