Analysis of Bacterial Uptake & Growth within Mammalian Cells

Kerri-Lynn Sheahan
Postdoctoral Fellow
Ph.D Northwestern University, Chicago, IL

Thesis
Characterization of Three Activity Domains within the Multifunctional RTX toxin from Vibrio cholerae.

Current Research
Identification of host cell factors required for Yersinia Type III effector cytotoxicty.

Publications

1. Sheahan KL, Cordero CL, and Satchell KJ. Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain. EMBO J. (2007) 16;26(10):2552-61.
2. Sheahan KL and Satchell KJ. Inactivation of small Rho GTPases by the multi-functional RTX toxin from Vibrio cholerae. Cell Microbiol. (2007) 9(5):1324-1335.
3. Sheahan KL, Cordero CL, and Satchell KJ. Identification of a Domain Within the Multi- functional Vibrio cholerae RTX Toxin that Covalently Cross-links Actin. Proc. Natl. Acad. Sci. USA (2004) 101(26):9798-803.