Analysis of Bacterial Uptake & Growth within Mammalian Cells
Isberg Laboratory


Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111

Lab (617) 636-4092
   

Matt Heidtman
Post-doctoral fellow
Ph.D. Dartmouth Medical School 2005
B.A. Skidmore College 1996

Thesis
Investigation of Yip1p function in transport between the ER and the Golgi complex

Current Research
Identification and functional analysis of Legionella Dot/Icm substrates involved in phagosomal remodeling

Publications

  1. Heidtman M, Chen EJ, Moy MY, Isberg RR. 2009. Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways.  Cell Microbiol. 11(2):230-248.

  2. Isberg RR, O'Connor T, Heidtman M.  2009. The Legionella pneumophila replication vacuole: making a cozy niche inside host cells. Nat Rev Microbiol. 7(1):13-24.

  3. O'Connor, T, Heidtman, M and Isberg, RR 2007. Mechanisms of Intracellular Survival and Replication of Legionella pneumophila. In Legionella: Molecular Microbiology. Horizons Press, NY.

  4. Conover GM, Martinez-Morales F, Heidtman MI, Luo ZQ, Tang M, Chen C, Geiger O, Isberg RR. 2007. Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol. 10(2):514-528.

  5. Heidtman M, Chen CZ, Collins RN, Barlowe C. 2005. Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Mol Biol Cell. 16(4):1673-1683.

  6. Chen CZ, Calero M, DeRegis CJ, Heidtman M, Barlowe C, Collins RN. 2004. Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor. Genetics. 168(4):1827-1841.

  7. Kumar A, Seringhaus M, Biery MC, Sarnovsky RJ, Umansky L, Piccirillo S, Heidtman M, Cheung KH, Dobry CJ, Gerstein MB, Craig NL, Snyder M. 2004. Large-scale mutagenesis of the yeast genome using a Tn7-derived multipurpose transposon. Genome Res. 14(10A):1975-1986.

  8. Heidtman M, Chen CZ, Collins RN, Barlowe C. 2003. A role for Yip1p in COPII vesicle biogenesis. J Cell Biol. 163(1):57-69.

  9. Kumar A, Agarwal S, Heyman JA, Matson S, Heidtman M, Piccirillo S, Umansky L, Drawid A, Jansen R, Liu Y, Cheung KH, Miller P, Gerstein M, Roeder GS, Snyder M. 2002. Subcellular localization of the yeast proteome. Genes Dev. 16(6):707-719.

  10. Otte S, Belden WJ, Heidtman M, Liu J, Jensen ON, Barlowe C. 2001. Erv41p and Erv46p:new components of COPII vesicles involved in transport between the ER and the Golgi complex. J Cell Biol. 152(3):503-518.