Principal Investigator
David Lazinski
Assistant Professor
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Program Affiliations
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-3671
Lab (617) 636-0474
Fax (617) 636-0337
Send Email |
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Our lab studies the Hepatitis delta virus (HDV), a subviral
agent which requires the presence of Hepatitis B virus to
produce infectious virions. Chronic HDV infections often lead
to a severe form of hepatitis, in which infected individuals
suffer a greater risk of developing fulminant hepatitis, liver
cirrhosis, and hepatocellular carcinoma. HDV replication has
several intriguing features. Among these are the presence
of catalytic RNAs, use of RNA editing to express two proteins
from a single open reading frame, and RNA templated transcription
by a host polymerase. |
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