Anaerobic Pathogens


Principal Investigator
Michael Malamy
Professor

Program Affiliations
Genetics
Molecular Microbiology

Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111

Office (617) 636-6756
Lab (617) 636-6757
Fax (617) 636-0337
Email  
Michael.Malamy@tufts.edu
  1. Brigham, C and M.H. Malamy. 2004. Characterization of the RokA and HexA broad substrate specificity hexokinases from Bacteroides fragilis and their role in hexose and N-acetylglucosamine utilization. J Bacteriol (in press).
  2. Baughn A.D. and M.H. Malamy. 2004. The strict anaerobe Bacteroides fragilis grows in and benefits from nanomolar concentrations of oxygen. Nature. 427:441-4
  3. Baughn A.D. and M.H. Malamy. 2003. The essential role of fumarate reductase in haem-dependent growth stimulation of Bacteroides fragilis. Microbiology. 149(Pt 6):1551-8
  4. Shi D, Gallegos R, DePonte J 3rd, Morizono H, Yu X, Allewell NM, Malamy M, Tuchman M. 2002. Crystal structure of a transcarbamylase-like protein from the anaerobic bacterium Bacteroides fragilis at 2.0 A resolution. J Mol Biol. 19;320(4):899-908.
  5. Caldovic L, Morizono H, Yu X, Thompson M, Shi D, Gallegos R, Allewell NM, Malamy MH, Tuchman M. 2002. Identification, cloning and expression of the mouse N-acetylglutamate synthase gene. Biochem J. 15;364(Pt 3):825-31.
  6. Baughn AD, Malamy MH. 2002. From the Cover: A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: Implications for the evolution of the mitochondrial Krebs cycle. Proc Natl Acad Sci U S A. 2;99(7):4662-7.
  7. Chen T, Dong H, Tang YP, Dallas MM, Malamy MH, Duncan MJ. 2000. Identification and cloning of genes from Porphyromonas gingivalis after mutagenesis with a modified Tn4400 transposon from Bacteroides fragilis. Infect Immun. 68(1):420-3.
  8. Tang YP, Malamy MH. 2000. Isolation of Bacteroides fragilis mutants with in vivo growth defects by using Tn4400', a modified Tn4400 transposition system, and a new screening method. Infect Immun.68(1):415-9.
  9. Tang YP, M.M. Dallas and M.H. Malamy. 1999. Characterization of the BatI (Bacteroides Aerotoloerance) Operon in Bacteroides fragilis: Isolation of a B. fragilis mutant with reduced aerotolerance and impaired growth in in vivo model systems. Molecular Microbiology 32:139-149. PubMed
  10. Rajagopal, B.S., J. DePonte III, M. Tuchman and M.H. Malamy. (1998) Use of feedback resistant N-acetylglutamate synthetase for enhanced biosynthesis of arginine by engineered E. coli K12 strains. Applied Environ. Micro. 64:1805-1811. PubMed