Messenger RNA Processing

Susan Lee
Postdoctoral Associate
Ph.D., Cornell University, Department of Molecular Biology and Genetics
B.S., Washington University in St. Louis, Chemistry

Thesis Topic
Analysis of Saccharomyces cerevisiae MSH and MLH proteins in mismatch recognition and post recognition steps in DNA mismatch repair

Current Research
My project involves dissecting molecular mechanisms of mRNA 3' end processing in the yeast Saccharomyces cerevisiae. I am specifically interested in how mRNA 3' end processing is regulated by post-translational modifications of the factors that catalyze the processing.

Publications

1. Lee, SD, Surtees, JA, and Alani E. 2007. Saccharomyces cervisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition. J. Mol. Biol. 366(1):53-66.
2. Lee, SD and Alani E. 2006. Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA. J. Mol. Biol. 355(2): 175-84.
3. Wang, H., Yang Y., Schofield, MJ, Du, C., Fridman, Y, Lee, SD, Largon ED, Drummond, JT, Alani, E, Hsieh, P. and Erie, DA. 2003. DNA bending and unbending by MutS govern mismatch recognition and specificity. Proc. Natl. Acad. Sci., USA 100(25): 14822-14827.
4. Sun, FL, Haynes, K, Simpson, CL, Lee, SD, Collins, L, Wuller, J., Eissenberg, JC and Elgin, SC. 2004. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol. Cell. Biol. 24(18): 8210-8220.