Principal Investigator
Claire Moore
Professor
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Program Affiliations
Biochemistry
Genetics
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-6935
Lab (617) 636-3645
Fax (617) 636-0337
Send Email |
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Selected Publications
Qu, X, Perez-Canadillas, J.-M.,
Agrawal, S., De Baecke. J., Cheng, H., Varani, G.,
and Moore, C. 2007. The C-terminal domains
of vertebrate CstF-64 and its yeast orthologue Rna15
form a new structure critical for mRNA 3’-end
processing. In press, J. Biol. Chem.
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Kim, M., Vasiljeva, L., Rando,
O., Zhelkovsky, A., Moore, C. and Buratowski, S.
2006. Distinct mechanisms for snoRNA and mRNA
termination. Mol. Cell. 24:723-734.
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Zhelkovsky, A., Tacahashi, Y.,
Nasser, T., He, X., Sterzer, U., Jensen, T., Domdey,
H., and Moore, C. 2006. The role of the
Brr5/Ysh1 C-terminal domain and its homolog, Syc1,
in mRNA 3’ end processing in Saccharomyces
cerevisiae. RNA 12:435-445
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He, X., and C. Moore. 2005.
Regulation of yeast mRNA 3' end processing by phosphorylation. Mol
Cell. 19:619-629
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Moore, C. and T. Jensen 2005. Reviving
the exosome. Cell 121:660-622.
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Krishnamurthy, S., X. He, M.
Reyes-Reyes, C. Moore, and M. Hampsey. 2004. Ssu72
is a novel RNA polymerase II CTD phosphatase. Mol.
Cell. 14:387-394
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Zhelkovsky A., S. Helmling, A.
Bohm, C. Moore. 2004. Mutations in the middle domain
of yeast poly(A) polymerase affect interactions with
RNA but not ATP. RNA. 10:558-64.
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Cheng H., X. He and C. Moore. 2004.
The essential WD repeat protein Swd2 has dual functions
in RNA polymerase II transcription termination and
lysine 4 methylation of histone H3. Mol Cell Biol. 24:2932-43.
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Nedea E., X. He, M. Kim, J. Pootoolal,
G. Zhong, V. Canadien, T. Hughes, S. Buratowski, C.L.
Moore and J. Greenblatt. 2004. Organization and function
of APT, a subcomplex of the yeast cleavage and polyadenylation
factor involved in the formation of mRNA and small
nucleolar RNA 3'-ends. J Biol Chem. 278:33000-10.
Epub 2003 Jun 20.
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Tacahashi Y., S. Helmling, C.L.
Moore. 2003. Functional dissection of the zinc finger
and flanking domains of the Yth1 cleavage/polyadenylation
factor. Nucleic Acids Res. 31:1744-52.
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He, X., Khan, A., Cheng, H., Pappas,
D., Hampsey, M., and Moore, C. 2003. Functional interactions
between the transcription and mRNA 3’ end processing
machineries mediated by Ssu72 and Sub1. (2003) Genes
and Development 17:1030-1042.
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