Rosenberg Laboratory [Program Faculty]

Abl Oncogenes and Mechanisms of Cancer Development

Principal Investigator
Naomi Rosenberg
Professor
 
Program Affiliations
Genetics
Immunology
Molecular Microbiology
 
Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-2143
Lab (617) 636-0307
Fax (617) 636-0337
Send Email

Selected Publications

Desgranges, Z. P., Ahn, J., Lazebnik, M., Ashworth, T., Lee, C., Pestell, R. C., Rosenberg, N., Prives, C., and Roy, A. L. 2005. Inhibition of TFII-I-dependent cell cycle regulation by p53. Mol. Cell. Biol. 25, 10940-10952.
[Abstract]
Marchlik, E., Kalman, R., and Rosenberg, N. 2005. Decreased virus population diversity in p53 null mice infected with weakly oncogenic Abelson virus. J. Virol. 79: 11618-11626.
[Abstract]
Baughn, L. B. and Rosenberg, N. 2005. Disruption of the Shc/Grb2 complex during Abelson virus transformation affects proliferation, but not apoptosis. J. Virol. 79:2325-2334.
[Abstract]
Sachs, Z., Sharpless, N. E., DePinho, R. A., and Rosenberg, N. 2004. p16Ink4a interferes with Abelson virus transformation by enhancing apoptosis. J. Virol. 78: 3304-3311.
[Abstract]
Kharas, M. G., Deane, J. A., Wong, S., O'Bosky, K. R., Rosenberg, N., Witte, O. N., and Fruman, D. A. 2004. Phosphoinositide 3-kinase is essential for Abl oncogene mediated transformation of B lineage cells. Blood 103: 4268-4275.
[Abstract]
Gong, L., Unnikrishnan, I., Raghavan, A., Parmar, K. and Rosenberg, N. 2004. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. J. Virol. 78: 1636-1644.
[Abstract]
Unnikrishnan, I. and Rosenberg, N. 2003. The absence of p53 complements defects in Abelson murine leukemia virus signaling. J. Virol. 77: 6208-2003.
[Abstract]
Warren, D. W., Griffin, D., Mainville, C. A., and Rosenberg, N. 2003. The carboxyl terminus of v-Abl mediates protein stability in pre-B lymphocytes. J. Virol. 77: 4617-4625.
[Abstract]
Rosenberg, N. 2001. New transformation tricks from a barnyard retrovirus - Implications for human lung cancer. Proc. Natl. Acad. Sci. U. S. A. 98: 4285-4287.
[Abstract]
Mainville, C., Parmar, K., Unnikrishnan, I. Raffel G. D., Gong, L., and Rosenberg, N. 2001. Alteration of the FLVRES motif in the v-Abl SH2 domain confers a temperature sensitive transformation phenotype. J. Virol. 75:1816-1823.
[Abstract]
Warren, D., Heilpern, A. J., Berg, K., and Rosenberg, N. 2000. The carboxyl terminus of v-Abl protein can augment SH2 domain function. J. Virol. 74: 4495-4504.
[Abstract]
Mostecki, J., Halgren, A. Sachs, Z., Radfar, A., Ravitz, J., Thome, K. C., and Rosenberg, N. 2000. Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells. J. Virol. 74: 9479-9487.
[Abstract]
Jenab-Wolcott, J., Rodriguez-Correa, D., Reitmair, A., Mak, T., and Rosenberg, N. 2000. The absence of Msh2 alters Abelson virus pre-B cell transformation by influencing p53 mutation. Mol. Cell. Biol. 20: 8373-8381.
[Abstract]
Unnikrishnan, I., Radfar, A., Jenab-Wolcott, J., and Rosenberg, N. 1999. p53 mediates apoptotic crisis in primary Ab-MLV-transformed pre-B cells. Mol. Cell. Biol. 19: 4825-4831.
[Abstract]
Coffin, J. M. and Rosenberg, N. 1999. Retroviruses. Closing the joint. Nature 413: 415-416.
[Abstract]
Radfar, A., Unnikrishnan, I., Lee, H.-W., DePinho, R., and Rosenberg, N.1998. p19ARF induces p53-dependent apoptosis during Abelson virus-mediated pre-B cell transformation. Proc. Natl. Acad. Sci. U.S.A. 95: 13194-13199.
[Abstract]
Thome, K., Radfar, A., and Rosenberg, N. 1997. Mutations in Tp53 contribute to the malignant phenotype of Abelson virus-transformed cells. J. Virol. 71: 8149-8156.
[Abstract]
Liu, D. J. Jenab, and N. Rosenberg. 1997. kappa and lambda rearrangement occur simultaneously in transformed pre-B cells. J. Immunol. 159: 6061-6069.
[Abstract]
Afar, D. E. H., Han, L., McLaughlin, J., Wong, S., Dhaka, A., Parmar, K., Rosenberg, N., Witte, O. N., and Colicelli, J. 1997. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Immunity 6: 773-782.
[Abstract]
Bailey, S. N. and N. Rosenberg. 1997. Assessing the pathogenic potential of the V(D)J recombinase by interlocus immunoglobulin light chain gene rearrangement. Mol. Cell. Bio. 17: 887-894.
[Abstract]
Rosenberg, N. and Jolicoeur, P. 1997. Retrovirus Pathogenesis, in Retroviruses, J. Coffin, S. Hughes, and H. Varmus, eds., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp 475-586.
[Abstract]
 

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Program in Molecular Microbiology
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