We are interested in regulation of mammalian cell growth and cellular signal transduction. The lab is particularly interested in protein phosphorylation Most of our work starts from issues raised by polyomavirus, a small DNA tumor virus. Polyomaviruses subvert host cell mechanisms for its replication and transcription. The ability of the virus to transform is based on its early proteins: large T (LT), middle T (MT) and small T (ST) antigens and their actions in the cell.

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