Principal Investigator
Brian Schaffhausen
Professor and Chair of Biochemistry
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Program Affiliations
Biochemistry
Genetics
Molecular Microbiology
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Contact Information
Department of Biochemistry
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-6876
Lab (617) 636-6868
Fax (617) 636-2409
Send Email |
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Selected Publications
Gunther U, Mittag T, Schaffhausen
B. Probing Src homology 2 domain ligand interactions
by differential line broadening. Biochemistry. 2002
Oct 1;41(39):11658-69.
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Gunther UL, Schaffhausen B. NMRKIN:
simulating line shapes from two-dimensional spectra
of proteins upon ligand binding. J Biomol NMR. 2002
Mar;22(3):201-9. Review.
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Tian X, Rusanescu G, Hou W, Schaffhausen
B, Feig LA. PDK1 mediates growth factor-induced Ral-GEF
activation by a kinase-independent mechanism. EMBO
J. 2002 Mar 15;21(6):1327-38.
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Weber T, Schaffhausen B, Liu Y,
Gunther UL. NMR structure of the N-SH2 of the p85 subunit
of phosphoinositide 3-kinase complexed to a doubly
phosphorylated peptide reveals a second phosphotyrosine
binding site. Biochemistry. 2000 Dec 26;39(51):15860-9.
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Sheng Q, Love TM, Schaffhausen
B. J domain-independent regulation of the Rb family
by polyomavirus large T antigen. J Virol. 2000 Jun;74(11):5280-90.
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Yen A, Cherington V, Schaffhausen
B, Marks K, Varvayanis S. Transformation-defective
polyoma middle T antigen mutants defective in PLCgamma,
PI-3, or src kinase activation enhance ERK2 activation
and promote retinoic acid-induced, cell differentiation
like wild-type middle T. Exp Cell Res. 1999 May 1;248(2):538-51.
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Mullane KP, Ratnofsky M, Cullere
X, Schaffhausen B. Signaling from polyomavirus middle
T and small T defines different roles for protein phosphatase
2A. Mol Cell Biol. 1998 Dec;18(12):7556-64.
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Chou MM, Hou W, Johnson J, Graham
LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker
A. Regulation of protein kinase C zeta by PI 3-kinase
and PDK-1. Curr Biol. 1998 Sep 24;8(19):1069-77.
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Sverdrup F, Schaffhausen BS, Androphy
EJ. Polyomavirus large T can support DNA replication
in human cells. Virology. 1998 Jan 5;240(1):50-6.
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| Cullere X, Rose P, Thathamangalam
U, Chatterjee A, Mullane KP, Pallas DC, Benjamin TL,
Roberts TM, Schaffhausen BS. Serine 257 phosphorylation
regulates association of polyomavirus middle T antigen
with 14-3-3 proteins. J Virol. 1998 Jan;72(1):558-63. |
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