Bacillus subtilis & Clostridium difficile

Laurent Bouillaut
Postdoctoral Associate
Ph.D INA-PG France

Thesis Topic
Molecular basis for a quorum sensing system in Bacillus cereus.

Current Research
Construction of new genetic tools in Clostridium difficile.
Quorum sensing and sporulation in Clostridium difficile.

Publications: 

1. Bouillaut L, Perchat S, Arold S, Zorrilla S, Slamti L, Henry C, Gohar M, Declerck N, Lereclus D. Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides. Nucleic Acids Res. 2008 Jun;36(11):3791-801.
2. Declerck N, Bouillaut L, Chaix D, Rugani N, Slamti L, Hoh F, Lereclus D, Arold ST. Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18490-5.
3. Gilois N, Ramarao N, Bouillaut L, Perchat S, Aymerich S, Nielsen-Leroux C, Lereclus D, Gohar M. Growth-related variations in the Bacillus cereus secretome. Proteomics. 2007 May;7(10):1719-28.
4. Bouillaut L, Ramarao N, Buisson C, Gilois N, Gohar M, Lereclus D, Nielsen-Leroux C. FlhA influences Bacillus thuringiensis PlcR-regulated gene transcription, protein production, and virulence. Appl Environ Microbiol. 2005 Dec;71(12):8903-10