Principal Investigator
Abraham L. Sonenshein
Professor
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Program Affiliations
Genetics
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-6761
Lab (617) 636-6762
Fax (617) 636-0337
Send Email |
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Selected Publications
Picossi, S., B. R. Belitsky,
and A. L. Sonenshein (2006) Molecular mechanism of
the regulation of Bacillus subtilis gltAB expression
by GltC. J. Mol. Biol. (in press)
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Shivers, R. P., S. Dineen, and
A. L. Sonenshein (2006) Positive regulation of Bacillus
subtilis ackA by CodY and CcpA: establishing
a potential hierarchy in carbon flow. Mol. Microbiol.
62: 811–822.
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Serio, A. W., K. B. Pechter,
and A. L. Sonenshein (2006) Bacillus subtilis aconitase
is required for efficient late sporulation gene expression.
J. Bacteriol. 188:6396-6405.
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Serio, A. W., and A. L. Sonenshein
(2006) Expression of yeast mitochondrial aconitase
in Bacillus subtilis. J. Bacteriol. 188:6406-6410.
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Levdikov, V. M., E. Blagova,
P. Joseph, A. L. Sonenshein and A. J. Wilkinson (2006)
The structure of CodY, a GTP- and isoleucine-responsive
regulator of stationary phase and virulence in gram-positive
bacteria. J. Biol. Chem. 281:11366-11373.
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Mani, N., B. Dupuy, and A. L.
Sonenshein (2006) Isolation of RNA polymerase from Clostridium
difficile and characterization of glutamate
dehydrogenase and rRNA gene promoters in vitro and
in vivo. J. Bacteriol. 188:96-102.
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Dupuy, B., S. Raffestin, S. Matamouros,
N. Mani, M. R. Popoff, and A. L. Sonenshein (2006)
Regulation of toxin and bacteriocin gene expression
in Clostridium by interchangeable RNA polymerase
sigma factors. Mol. Microbiol. 60:1044-1057.
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Kim, H.-J., M. Mittal, and A.
L. Sonenshein (2006) CcpC-dependent regulation of citB and
lmo0847 in Listeria monocytogenes. J. Bacteriol.188:179-190.
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Joseph, P., M. Ratnayake-Lecamwasam,
and A. L. Sonenshein. 2005. A region of B. subtilis
CodY protein required for interaction with DNA. J.
Bacteriol. 187:4127-4139.
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Shivers, R. P., and A.
L. Sonenshein. 2005. Bacillus subtilis ilvB operon:
an intersection of global regulons. Mol. Microbiol.
56:1549-1559.
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Dupuy, B., N. Mani, S.
Katayama, and A. L. Sonenshein. 2005. Transcription
activation of a UV-inducible Clostridium perfringens
bacteriocin gene by a novel ? factor. Mol. Microbiol.
55:1196-1206.
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Shivers, R. P., and A. L. Sonenshein.
2004. Activation of the Bacillus subtilis global regulator
CodY by direct interaction with branched-chain amino
acids. Mol. Microbiol. 53:599-611.
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Belitsky, B., and A. L. Sonenshein.
2004. Modulation of activity of Bacillus subtilis regulatory
proteins GltC and TnrA by glutamate dehydrogenase.
J. Bacteriol. 186:3399-3407.
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Belitsky, B., H. J. Kim, and A.
L. Sonenshein. 2004. CcpA-dependent regulation of Bacillus
subtilis glutamate dehydrogenase synthesis. J. Bacteriol.
186:3392-3398.
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Kim, H.-J., S.-I. Kim, M. Ratnayake-Lecamwasam,
K. Tachikawa, A. L. Sonenshein, and M. Strauch. 2003.
Complex regulation of the Bacillus subtilis aconitase
gene. J. Bacteriol. 185:1672-1680.
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Haraldsen, J. and A. L. Sonenshein.
2003. Efficient sporulation in Clostridium difficile
requires disruption of the sigmaK gene. Mol. Microbiol.
48: 811-821.
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Kim, S.-I., C. Jourlin-Castelli,
S. R. Wellington and A. L. Sonenshein. 2003. Mechanism
of repression by Bacillus subtilis CcpC, a LysR family
regulator. J. Mol. Biol. 334:609-624.
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Molle, V., Y. Nakaura, R. P. Shivers,
H. Yamaguchi, R. Losick, Y. Fujita, and A. L. Sonenshein.
2003. Additional targets of the Bacillus subtilis global
regulator CodY identified by chromatin immunoprecipitation
and genome-wide transcript analysis. J. Bacteriol.
185:1911-1922.
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Blagova, E., V. M. Levdikov, K.
Tachikawa, A. L. Sonenshein, and A. J. Wilkinson. 2002.
Crystallization of the GTP-dependent transcriptional
regulator CodY from Bacillus subtilis. Acta Crystall.
D59:155-157.
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Mani, N., D. Lyras, L. Barroso,
P. Howarth, T. Wilkins, J. I. Rood, A. L. Sonenshein,
and B. Dupuy. 2002. Environmental response and autoregulation
of Clostridium difficile TxeR, a sigma factor for toxin
gene expression. J. Bacteriol. 184:5971-5978. PubMed
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Belitsky, B. R., and A. L. Sonenshein.
2002. GabR, a member of a novel protein family, regulates
utilization of gamma-aminobutyrate in Bacillus subtilis.
Mol. Microbiol. 45:569-583. PubMed
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Kim, H.-J., A. Roux, and A. L.
Sonenshein. 2002. Direct and indirect roles of CcpA
in regulation of Bacillus subtilis Krebs cycle genes.
Mol. Microbiol. 45:179-190. PubMed
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Kim, H.-J., C. Jourlin-Castelli,
S.–I. Kim, and A. L. Sonenshein. 2002. Regulation
of the Bacillus subtilis ccpC gene by CcpA
and CcpC. Mol. Microbiol. 43:399-410. PubMed
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Ratnayake-Lecamwasam, M., P. Serror,
K.-W. Wong, and A. L. Sonenshein. 2001. Bacillus
subtilis CodY represses early stationary phase
genes by sensing GTP levels. Genes Dev. 15:1093-1103. PubMed
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Belitsky, B. R., L. V. Wray, Jr.,
S. H. Fisher, D. E. Bohannon, and A. L. Sonenshein.
2000. Role of TnrA in nitrogen source-dependent repression
of Bacillus subtilis glutamate synthase gene
expression. J. Bacteriol. 182:5939-5947. PubMed
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Jourlin-Castelli, C., N. Mani, M.
Nakano, and A. L. Sonenshein. 2000. CcpC, a novel regulator
of the LysR family required for glucose repression
of the citB gene in Bacillus subtilis.
J. Mol. Biol. 295:865-878. PubMed
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Alén, C., and A. L. Sonenshein.
1999. Bacillus subtilis aconitase is an RNA-binding
protein. Proc. Natl. Acad. Sci. 96:10412-10417. PubMed
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Belitsky, B. R., and A. L. Sonenshein.
1999. An enhancer element located downstream of the
major glutamate dehydrogenase gene of Bacillus
subtilis. Proc. Natl. Acad. Sci. 96:10290-10295. PubMed
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Matsuno, K., T. Blais, A. W. Serio,
T. Conway, T. M. Henkin, and A. L. Sonenshein. 1999.
Metabolic imbalance and sporulation in an isocitrate
dehydrogenase mutant of Bacillus subtilis.
J. Bacteriol. 181:3382-3391. PubMed
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Belitsky, B., and A. L. Sonenshein.
1998. Role and regulation of Bacillus subtilis glutamate
dehydrogenase genes. J. Bacteriol. 180:6298-6305. PubMed
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| Dupuy, B., and A. L. Sonenshein.
1998. Regulated transcription of the Clostridium
difficile toxin genes. Molec. Microbiol. 27:107-120. PubMed |
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