Principal Investigator
Catherine Squires
Professor and Chair
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Program Affiliations
Molecular Microbiology
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Contact Information
Department of Microbiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-6947
Lab (617) 636-6822
Fax (617) 636-0337
Send Email |
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Selected Publications
Cruz-Vera, L.R., S. Rajagopal, C.
L. Squires and C Yanofsky. 2005. Features of Ribosome-Peptidyl-tRNA
Interactions Essential for Tryptophan Induction of tna Operon
Expression. Mol Cell 19:333-343.
PubMed
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Quan, S., N. Zhang, S. French, and
C. L. Squires. 2005. Transcriptional Polarity in rRNA
Operons in Escherichia coli nusA and nusB Mutant
Strains. . J. Bacteriol. 187,
1632-1638.
PubMed
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Torres, M., J.-M. Balada, M. Zellars,
C. Squires, and C. L. Squires. (2004) In vivo effect
of NusB and NusG on rRNA transcription antitermination.
. J. Bacteriol. 186:1304-1310.
PubMed
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Zaporojets, D. S. French, and C.
L. Squires. 2003. Products transcribed from fragmentedand
rearranged rrn genes of E. coli can
assemble to form functional ribosomes. J. Bacteriol. 185:6921-6927.
PubMed
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Seoh, H-K, M. Weech, N. Zhang, and
C. L. Squires. 2003. Ribosomal RNA Antitermination
Functions with Heat Shock Promoters. J. Bacteriol 185:6486-6489.
PubMed
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O’Connor, M., W.-C. M. Lee,
A. Mankad, C. L. Squires, and A. E. Dahlberg. 2001.
Mutagenesis of the peptidyltrasferase center of 23S
rRNA: the invariant U2449 is Dispensable. Nuc.
Acids Research. 29:710-715. PubMed
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Torres, M, C. Condon, J.-M. Balada,
C. Squires and C. L. Squires. 2001. Ribosomal protein
S4 is a transcription factor with properties remarkably
similar to NusA, a protein involved in both non-ribosomal
and ribosomal RNA antitermination. The EMBO J. 20:3811-3820. PubMed
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Voulgaris, J., D. Pokholok, W. M.
Holmes, C. Squires and C. L. Squires. 2000. The feedback
response of E. coli rRNA synthesis is not
identical to the mechanism of growth rate-dependent
control. J. Bacteriol. 182:536-539. PubMed
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Moine, H., C. L. Squires, B. Ehresmann
and C. Ehresmann. 2000. In vivo selection of functional
ribosomes with variations in the rRNA-binding site
of E. coli ribosomal protein S8: Evolutionary
implications Proc. Natl. Acad. Sci USA 97:605-610. PubMed
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Gabashvili, I.S., R.K. Agrawal,
R. Grassucci, C. L. Squires, A.E. Dahlberg and J. Frank.
1999. Major rearrangements in the 70S ribosomal 3D
structure are caused by a conformational switch in
16S ribosomal RNA. EMBO J 18:6501-6507. PubMed
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Vila, A., C. L. Squires and A.E.
Dahlberg. 1999. Isolation of kasugamycin resistant
mutants in the 16S ribosomal RNA of Escherichia
coli. J. Mol. Biol. 293:1-8. PubMed
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O'Conner, M., T. Asai, C. L. Squires
and A. Dalhberg. 1999. Enhancement of Translation
by the Downstream Box Does Not Involve Base Pairing
of mRNA with the penultimate stem sequence of 16S rRNA. Proc.
Natl. Acad. Sci. USA 96:8973-8978. PubMed
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Voulgaris, J., S. French, R. Gourse,
C. Squires and C. L. Squires. 1999. Increased rrn gene
dosage causes intermittent transcription of rRNA in Escherichia
coli. J. Bacteriol 181:4170-4175. PubMed
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Asai, T., C. Condon, J. Voulgaris,
D. Zaporojets, B. Shen, M. Al-Omar, C. Squires and
C. L. Squires. 1999. Construction and initial characterization
of E. coli strains with few or no intact chromosomal
rRNA operons. J. Bacteriol 181:3803-3809. PubMed
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Zellars, M. and C.L. Squires. 1999.
Antiterminator-dependent modulation of transcription
elongation rates by NusB and NusG. Mol Microbiol 32:
1296-1304. PubMed
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| Asai, T., D. Zaporojets, C. Squires
and C.L. Squires. 1999. An E. coli strain
with all chromosomal rRNA operons inactivated: Complete
exchange of rRNA genes between bacteria. Proc. Natl.
Acad. Sci. USA 96:1971-1976. PubMed |
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