Adjunct Associate Professor
General Manager Gentest
BD Biosciences
6 Henshaw Street
Woburn, MA 01801
Phone: 781-935-5115
Email: Charles_Crespi@bd.com

Research Interests:

Dr. Crespi is investigating novel methods for drug discovery support using heterologously-expressed human drug metabolizing enzymes. Recent approaches focus on developing fluorometric probe substrates for human P450s.

Recent Publications:

Venkatakrishnan, Karthik, LL von Moltke, MH Court, JS Harmatz, CL Crespi and DJ Greenblatt (2000). Comparison Between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from CDNA-Expressed CYPS to Human Liver Microsones: Ratios of Accessory Proteins as Sources of Discrepancies Between the Approaches. Drug Metabolism and Disposition 28, 1493-1504.

Stresser, DM, AP Blanchard, SD Turner, JCL Erve, AA Dandeneau, VP Miller, and CL Crespi (2000). Susbrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates. Drug Metabolism and Disposition 28, 1440-1448.

Crespi, CL, L Fox, P Stocker, MHu, and D Steimel-Crespi (2000). Analysis of drug transport and metabolism in cell monolayer systems that have been modified by cytochrome P4503A4 cDNA-expression. European Journal of Pharmaceutical Sciences 12, 63-68.

Chauret, N, B Dobbs, RL Lackman, K Bateman, DA Nicoll-Griffith, DM Stresser, JM Ackermann, SD Turner, VP Miller, and CL Crespi (2001). The Use of 3-[2-(N,-Diethyl-N-Methylammonium)Ethyl]-7-Methoxy- 4 - Methylcourmarin (AMMC) as a Specific CYP2D6 Probe in Human Liver Microsomes. Drug Metabolism and Disposition 29, 1196-1200.