Professor and Chair
Dept. of Pharmacology & Experimental Therapeutics
Tufts University School of Medicine
136 Harrison Avenue
Boston, MA 02111
Phone: 617-636-6997
Email: DJ.Greenblatt@tufts.edu

Research Interests:

Dr. Greenblatt's research activities deal with the sequence of events between initial entry of a drug or other chemical into the body and its ultimate interaction with a specific receptor site mediating the drugs' pharmacologic action. These include: mechanisms of drug absorption from the gastrointestinal tract or other extravascular sites of administration; regulation and prediction of drug diffusion and/or transport to extravascular tissues; processes of drug metabolism and biotransformation by the Cytochromes P450 enzymes and by glucuronyl transferases; presystemic extraction by the liver and gastrointestinal tract mucosa; in vitro models of drug metabolism; mechanisms and consequences of drug interactions; ligand binding and altered chloride channel permeability of the GABA-benzodiazepine receptor complex; pharmacodynamic consequences of benzodiazepine agonist ligand binding; physiologic factors altering benzodiazepine ligand pharmacokinetics and receptor sensitivity; mechanisms of altered receptor function as a consequence of chronic drug exposure. Dr. Greenblatt collaborates closely with Dr. Court.

Recent Publications:

Ansell J, McDonough M, Harmatz JS, Greenblatt DJ. A randomized, double-blind trial of the interaction between cranberry juice and warfarin. J Thromb Thrombolysis. 2008; 25(1):112.

Perloff MD, von Moltke LL, Fahey JM, Greenblatt DJ. Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells. J Pharm Pharmacol. 2007; 59(7):947-53.

Cysneiros RM, Farkas D, Harmatz JS, von Moltke LL, Greenblatt DJ. Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine. Clin Pharmacol Ther. 2007; 82(1):54-62.

Han T, Harmatz JS, Greenblatt DJ, Martyn JA. Fentanyl clearance and volume of distribution are increased in patients with major burns. J Clin Pharmacol. 2007; 47(6):674-80.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF. Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice. Drug Metab Dispos. 2007; 35(7):1223-31.