Assistant Professor
Depts. Anesthesia Research and Pharmacology
Tufts University School of Medicine
136 Harrison Avenue
Boston, MA 02111
Phone: 617-636-2955
Email: James.Marchand@Tufts.edu

Research Interests:

Plasticity in sensory processing. Two major sensory systems are studied in our laboratory: (1) somatosensory, with emphasis on pain processing, and (2) olfactory, with emphasis on olfactory receptor function and expression.

Technical approaches: Molecular biology: RT/PCR, cloning, sequencing, northern/southern blot hybridization, library screening, in vivo transfection and expression, quantitation of mRNA expression. Anatomical: Fluorescence immunohistochemistry, TUNL assay, in situ hybridization, receptor autoradiography.

Recent Publications:

Marchand J.E., Jesurum, A., Chikaraishi, D., and J. S. Kauer. Cloning and pattern expression of odorant receptors in olfactory epithelium of the tiger salamander, Ambystoma tigrinum. Submitted.

Marchand, J.E., Cepeda, M.S., Carr, D.B., Wurm, W.H. and Kream R.M. Alterations in neuropeptide Y, tyrosine hydroxylase, and Y-receptor subtype distribution following spinal nerve injury to rats. Pain 79:187-200, 1999.

Marchand, J.E., Sant, G.R, Kream, R.M. Increased expression of substance P-encoding mRNA in bladder biopsies from patients with interstitial cystitis. Br. J. Urology, 81(2):224-8, 1998.

Nikulina, E., Marchand, J.E., Kream, R.M., and Miczek, K.A. Fos expression in the murine brainstem after a brief social stress: behavioral sensitization to cocaine. Brain Res 810(1-2):200-10, 1998.