Adjunct Assistant Professor
Dept. Drug Metabolism
Pfizer Inc., Central Research Division
Eastern Point Road
Groton, CT 06340
Phone: 860-441-6122
Email: ronald_s_obach@groton.pfizer.com

Research Interests:

Dr. Obach's major scientific interests include the application of enzyme kinetics to drug metabolism, in vitro-in vivo correlations for prediction of human pharmacokinetics and the mechanism of cytochrome P450.

Recent Publications:

Roussel F, Duignan DB, Lawton MP, Obach RS, Strick CA, Tweedie DJ. Expression and characterization of canine cytochrome P450 2D15. Arch Biochem Biophys 357(1):27-36, 1998.

Obach RS, Pablo J, Mash DC. Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine. Drug Metab Dispos 26(8):764-8, 1998.

Obach RS. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab Dispos 25(12):1359-69, 1997.

Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, Rance DJ, Wastall P. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J Pharmacol Exp Ther 283(1):46-58, 1997.