Adjunct Associate Professor
Dept. of Pharmacology & Experimental Therapeutics
Tufts University School of Medicine

Current Address:
Room X-847
650 Albany St
Department of Medicine
Boston Medical Center
Phone: 617-230- 8570

Email: Orian.Shirihai@tufts.edu

Visit the Shirihai research web site :http://www.shirihai-lab.org/

Research Interests:

Mitochondrial biology. Role of mitocondria in differentiation of blood projenitors, Role of mitochondria in pancreatic beta cell fuel sensing, Insulin secretion and Diabetes. Mitochondrial drug toxicity

Recent Publications:

Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med, 2008; [Epub ahead of print]

Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 17; [Epub ahead of print]

Haigh SE, Twig G, Molina AA, Wikstrom JD, Deutsch M, Shirihai OS. PA-GFP: a window into the subcellular adventures of the individual mitochondrion. Novartis Found Symp. 2007; 287:21-36; discussion 36-46.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007; 56(10):2569-78.

Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P. Direct interorganellar transfer of iron from endosome to mitochondrion. Blood. 2007; 110(1):125-32.

Twig G, Graf SA, Wikstrom JD, Mohamed H, Haigh SE, Elorza A, Deutsch M, Zurgil N, Reynolds N, Shirihai OS. Tagging and tracking individual networks within a complex mitochondrial web with photoactivatable GFP.
Am J Physiol Cell Physiol. 2006; 291(1):C176-84.