Director, Center for HIV/AIDS Care and Research
Boston Medical Center
Professor of Medicine
Boston University School of Medicine
Evans Biomedical Research Center
650 Albany Street, Room 647
Boston, MA 02118
Phone (617) 414- 3520
Email: Paul.Skolnik@bmc.org

Research Interests:

Paul R. Skolnik, M.D. is Chief, Section of Infectious Diseases, and Director, Center for HIV/AIDS Care and Research (CHACR) at Boston University Medical Center (BUMC). The CHACR oversees all the clinical care, clinical research, basic research, and teaching at BUMC. He is Professor of Medicine and attending physician at BUMC, and Adjunct Associate Professor of Medicine at Tufts University School of Medicine. He is board certified in both internal medicine and infectious diseases. Dr. Skolnik’s current basic research interests include cytokine and chemokine control of HIV-1 replication, and innate immune responses during HIV infection, especially in the lung. Patient-derived samples are used in these studies whenever possible to most closely mirror the in vivo situation. Dr. Skolnik has carried out many clinical trials of investigational immunotherapeutic and antiretroviral drug therapies for HIV infection. Dr. Skolnik serves on the Immunology Research Agenda Committee (RAC) of the NIH-funded AIDS Clinical Trials Group (ACTG), and is a member of the HIV Disease RAC of the ACTG. Dr. Skolnik directs the Massachusetts Department of Public Health (MDPH)-funded comprehensive HIV and HCV testing and counseling programs at BUMC, and also serves as director for MDPH-funded linkage to care and early intervention programs. He also has expertise inpatient care and clinical HIV/AIDS research design and methodology, and was Associate Program Director of the NIH-funded General Clinical Research Center (GCRC) at Tufts-New England Medical Center (T-NEMC), where he was responsible for the GCRC training program. Dr. Skolnik was Program Director for two NIH-funded T32 HIV training grants at T NEMC, one in HIV clinical research and the other in HIV pathogenesis research, and now is co-Director of an NIH-funded HIV clinical research training grant and Principal Investigator for a basic research infectious diseases pathogenesis training grant at BUMC.

Recent Publications:

Mathys JM, Melanson SM, Schiffer-Alberts DJ, Ioannidis JPA, Koziel H, Skolnik PR. NF κB modulates TNFα production by alveolar macrophages in asymptomatic HIV-seropositive individuals. J Immunol. 164:1588-1594, 2000.

Skolnik PR, Rabbi MF, Mathys J-M, Greenberg AS. Stimulation of peroxisome proliferator-activated receptors α and γ (PPARα and γ) blocks HIV-1 replication and TNFα production in acutely-infected primary blood cells, chronically-infected U1 cells, and alveolar macrophages from HIV-infected subjects. JAIDS. 31:1-10, 2002.

Skolnik, P. HIV Therapy-What Do We Know, and When Do We Know It? New England Journal of Medicine. 349: 2351-2352, 2003.

Perloff ES, Duan SX, Skolnik PR, Greenblatt DJ, von Moltke LL. Atazanavir: Effects on P-gp transport and CYP3A metabolism in vitro. Drug Metab Disp. 33(6):764-770, 2005.