The research focuses on the secretory mechanism and pathophysiological actions of mast cells. Diseases investigated include: atopic dermatitis, arthritis, coronary artery inflammation, interstitial cystitis, migraines and multiple sclerosis. These diseases worsen by stress and we have identified that mast cells both contain and respond to stress hormones. The techniques used include molecular biology, cell biology, and various microscopic techniques, as well as animal models for the target diseases in which mast cells are involved.
 

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CRH, BBB-Bioscience

Differential release of mast cell
mediators and the pathogenesis of
inflammation

Mast cells as targets of corticotropin releasing
factor and related peptides

Increased Numbers of Activated Mast Cells
in Endometriosis Lesions Positive for
Corticotropin-Releasing Hormone and
Urocortin

Mast cells as targets of corticotropinreleasing
factor and related peptides

Mast cells and mast cell mediators as targets
of dietary supplements

Critical role of mast cells in inflammatory diseases and
the effect of acute stress

Mast cells: the JEKYLL and HYDE of tumor growth

Neuroimmunoendocrine circuitry of the ‘brain-skin connection’