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Work in our department focuses on the mechanisms of drug action
and the exploration of new ways of using drugs to treat and cure
disease. The department is responsible for medical student education
in pharmacology offering coursework, tutoring, and summer internships,
and it has a Ph.D. program designed to prepare candidates for careers
in pharmacological research. Research areas of particular interest
to our department are outlined below (click on a topic for more
information):
A critical aspect of drug action is how drugs are processed by
the body. Pharmacokinetics is
the study of how drugs are absorbed, metabolized and eliminated.
Understanding pharmacokinetics is essential for conducting Clinical
Pharmacology research which involves the analysis of drug action
in human subjects.
A large amount of the research in our department is centered around
the area of Neuropharmacology.
This discipline focuses on drugs which act primarily on the central
nervous system. Within this broad category are projects aimed at
understanding the action of Neuropeptides,
an important class of signaling molecules found in the brain and
other tissues. In addition, researchers in our department are trying
to elucidate the mechanisms underlying the process of Drug
Abuse. Laboratories which concentrate on the field of Behavioral
Pharmacology analyze the behavioral effects of drugs which primarily
have their effect on the brain.
Many diseases involve disruption of particular organ systems or
our body's natural defense systems. Cardiovascular
Pharmacology explores the agents that can be used to intervene
in cardiovascular diseases. Immunopharmacology
is the study of drugs designed to augment or modulate the immune
system in disorders ranging form allergy to cancer to HIV/AIDS.
The genetic revolution has led to an explosion of information about
the specific genes or gene products that are targets of drug action.
Molecular Pharmacology involves
the characterization of these target drug receptors. The goal of
these studies is to understand the relationship between drug structure
and function. These experiments can provide the basis for rational
Drug Design in which a specific
chemical is synthesized and tested with a therapeutic target in
mind.
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