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Forgac Laboratory: Publications
Forgac,M. 2007. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nature Reviews Molecular Cell Biology 8, 917-929. [Text]
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Jefferies,K. and Forgac,M. 2008. Subunit H of the V-ATPase inhibits ATP hydrolysis of the free V1 domain by interaction with the rotary subunit F. J.Biol.Chem. 283, 4512-4519. [Text]
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Qi,J. and Forgac,M. 2007. Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity J.Biol.Chem. 282, 23743-24751. [Text]
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Wang,Y., Cipriano,D.J. and Forgac,M. 2007. Arrangement of subunits in the proteolipid ring of the V-ATPase. J.Biol.Chem. 282 34058-34065. [Text]
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Qi,J., Wang,Y. and Forgac,M. 2007. The vacuolar (H+)-ATPase: Subunit arrangement and in vivo regulation. J.Bioenerg.Biomemb. 39, 423-426. [Text]
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Hinton,A., Bond,S. and Forgac,M. 2007. V-ATPase functions in normal and disease processes. Eur.J.Physiol.Plugers Arch. (in press). [Text]
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Kawasaki-Nishi S, Yamaguchi A, Forgac M, Nishi T. 2007. Tissue specific expression of the splice variants of the mouse vacuolar proton-translocating ATPase a4 subunit. Biochem Biophys Res Comm. 364, 1032-1036. [Text]
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Zhang,Z., Inoue,T., Forgac,M.
and Wilkens,S. 2006. Localization of subunit C
(Vma5p) in the yeast vacuolar ATPase by immunoelectron
microscopy. FEBS Lett. 580, 2006-2010. [Text]
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Wang,Y., Inoue,T. and Forgac,M.
2005 Subunit a of the yeast V-ATPase participates
in bafilomycin binding. J.Biol.Chem. 280, 40481-40488.
[Text]
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Inoue,T. and Forgac,M. 2005.
Cysteine-mediated cross-linking indicates that
subunit C of the V-ATPase is in close proximity
to subunits E and G of the V1 domain and subunit
a of the V0 domain. J.Biol.Chem. 280, 27896-27903.
[Text]
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Shen R, Inoue T, Forgac,M, Porco
JA Jr. 2005. Synthesis of photoactivatable acyclic
analogues of the lobatamides J.Org.Chem 70, 3686-3692.
[Text]
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Shao,E. and Forgac,M. 2004 Involvement
of the Non-homologous Region of Subunit A of the
Yeast V-ATPase in Coupling and In Vivo Dissociation” J.Biol.Chem.
279, 48663-48670.
[Text]
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Wang,Y., Inoue,T. and Forgac,M.
2004 TM2 but not TM4 of subunit c” interacts
with TM7 of subunit a of the yeast V-ATPase as
defined by disulfide-mediated cross-linking J.Biol.Chem.
279, 44628-44638.
[Text]
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Wilkens,S. Inoue,T. and Forgac,M.
2004 Three-dimensional structure of the vacuolar
ATPase - localization of subunit H by difference
imaging and chemical cross-linking J.Biol.Chem.
279, 41942-41949.
[Text]
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Kawasaki-Nishi,S., Nishi,T.
and Forgac,M. 2003 Interacting helical surfaces
of the transmembrane segments of subunits a and
c’ of the yeast V-ATPase defined by disilfide-mediated
cross-linking. J.Biol.Chem. 278, 41908-41913.
[Text]
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Nishi,T., Kawasaki-Nishi,S.
and Forgac,M. 2003 Expression and function of the
mouse V-ATPase d subunit isoforms. J.Biol.Chem.
278, 46396-46402.
[Text]
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Shao,E., Nishi,T., Kawasaki-Nishi,S.
and Forgac,M. 2003 Mutational analysis of the non-homologous
region of subunit A of the yeast V-ATPase. J.Biol.Chem.
278, 12985-12991.
[Text]
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Nishi,T., Kawasaki-Nishi,S.
and Forgac,M. 2003. The first putative transmembrane
segment of subunit c" (Vma16p) of the yeast V-ATPase
is not necessary for function. J.Biol.Chem. 278,
5821-5827.
[Text]
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Nishi,T. and Forgac,M. 2002.
The Vacuolar (H+)-ATPases: Nature's most versatile
proton pumps. Nature Reviews in Molecular Cell
Biology 3, 94-103.
[Text]
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Arata,Y., Baleja,J. and Forgac,M.
2002. Localization of subunits D, E and G in the
yeast V-ATPase complex using cysteine-mediated
crosslinking to subunit B. Biochemistry 41, 11301-11307.
[Text]
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Arata,Y., Baleja,J.D. and Forgac,M.
2002. Cysteine-directed crosslinking to subunit
B suggests that subunit E forms part of the peripheral
stalk of theV-ATPase. J.Biol.Chem. 277, 3357-3363.
[Text]
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Kawasaki-Nishi,S., Bowers,K.,
Nishi,T., Forgac,M. and Stevens,T.H. 2001. The
amino-terminal domain of the V-ATPase a subunit
controls targeting and in vivo dissociation and
the carboxyl-terminal domain affects coupling of
proton transport and ATP hydrolysis. J.Biol.Chem.
276, 47411-47420.
[Text]
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Kawasaki-Nishi,S., Nishi,T.
and Forgac,M. 2001. Arg735 of the 100 kDa a subunit
of the yeast V-ATPase is essential for proton translocation.
Proc.Natl.Acad.Sci., U.S.A. 98, 12397-12402.
[Text]
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Wilkens,S. and Forgac,M. 2001.
Three-dimensional structure of the vacuolar ATPase
proton channel. J.Biol.Chem. 276 44064-44068.
[Text]
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Nishi,T., Kawasaki-Nishi,S.
and Forgac,M. 2001. Expression and localization
of the mouse homologue of the yeast V-ATPase 21-kDa
subunit c" (Vma16p). J.Biol.Chem. 276, 34122-34130.
[Text]
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Xu,T. and Forgac,M. 2001. Microtubules
are involved in glucose-dependent dissociation
of the yeast V-ATPase in vivo. J.Biol.Chem. 276,
24855-24861.
[Text]
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Kawasaki-Nishi,S., Nishi,T.
and Forgac,M. 2001. Yeast V-ATPase complexes containing
different isoforms of the 100 kDa a subunit differ
in coupling efficiency and in vivo dissociation.
J.Biol.Chem. 276, 17941-17948.
[Text]
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Xu,T. and Forgac,M. 2000. Subunit
D (Vma8p) of the Yeast Vacuolar (H+)-ATPase Plays
a Role in Coupling of Proton Transport and ATP
Hydrolysis. J.Biol.Chem. 275, 22075-22081.
[Text]
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Nishi,T. and Forgac,M. 2000.
Molecular cloning and expression of three isoforms
of the 100-kDa a subunit of the mouse V-ATPase.
J.Biol.Chem. 275, 6824-6830.
[Text]
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Vasilyeva,E., Liu,Q., MacLeod,K.J.,
Baleja,J.D. and Forgac,M. 2000. Cysteine Scanning
Mutagenesis of the Noncatalytic Nucleotide Binding
Site of the Yeast V- ATPase. J.Biol.Chem. 275,
255-260.
[Text]
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Forgac,M. 1999. Structure and
properties of the vacuolar (H+)-ATPases. J.Biol.Chem.
274, 12951-12954.
[Text]
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MacLeod,K.J., Vasilyeva,E.,
Merdek,K., Vogel,P.D. and Forgac,M. 1999. Photoaffinity
labeling of wild-type and mutant forms of the yeast
V-ATPase A subunit by 2-azido-[32P]-ADP. J.Biol.Chem.
274, 32869-32874.
[Text]
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Wilkens,S., Vasilyeva,E. and
Forgac,M. 1999. Structure of the vacuolar ATPase
by electron microscopy. J.Biol.Chem. 274, 31804-31810.
[Text]
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Xu.T., Vasilyeva,E. and Forgac,M.
1999 Subunit interactions in the clathrin-coated
vesicle V-ATPase complex. J.Biol.Chem. 274, 28909-28915.
[Text]
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Leng,X.H., Nishi,T. and Forgac,M.
1999. Transmembrane topography of the 100 kDa a
subunit (Vph1p) of the yeast vacuolar proton-translocating
ATPase. J.Biol.Chem. 274, 14655-14661.
[Text]
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| Forgac,M. 1999. The vacuolar
H+-ATPase of clathrin-coated vesicles is reversibly
inhibited by S-nitrosoglutathione. J.Biol.Chem.
274, 1301-1305. |
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Laboratory Information
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Principal Investigator
Michael Forgac
Professor
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Program Affiliations
Biochemistry
Cellular & Molecular Physiology
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Contact Information
Department of Physiology
Tufts University
136 Harrison Avenue
Boston, MA 02111
Office (617) 636-6939
Lab (617) 636-6922
Fax (617) 636-0445
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