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Rosenblatt Laboratory:
Publications
Monaghan P, Woznica I, Moza B, Sundberg EJ, Rosenblatt,
M. Recombinant expression and purification of the
N-terminal extracellular domain of the parathyroid
hormone receptor. Protein Expr. Purif. 2007 (In
Press).
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Thomas BE, Wittelsberger A, Woznica I, Hsieh
M, Monaghan P, Lee BK, Rosenblatt M. Cysteine at
position 217 in the intracellular loop 1 plays
a critical role in human parathyroid hormone receptor
type 1 membrane translocation and function. J of
Bone and Mineral Research 2007; 22: 609-616. [Text]
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Wittelsberger A, Thomas B, Mierke D, Rosenblatt
M, et al. Methionine acts as a "magnet" in
photoaffinity crosslinking experiments. FEBS Letters
2006; 580: 1872-1876. [Text]
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Wittelsberger A, Corich M, Thomas BE, Lee BK,
Barazza A, Czodrowski P, Mierke DF, Chorev M, Rosenblatt
M. The mid-region of parathyroid hormone (1-34)
serves as a functional docking domain in receptor
activation. Biochemistry 2006; 45: 2027-2034. [Text]
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Gan L, Alexander JM, Wittelsberger A, Thomas
B, Rosenblatt M. Large-scale purification and characterization
of human parathyroid hormone-1 receptor stably
expressed in HEK293S GnTI¯ cells. Protein
Expr. Purif. 2006; 47: 296-302. [Text]
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Kuperwasser C, Dessain S, Bierbaum
BE, Garnet D, Sperandio K, Gauvin GP, Naber SP,
Weinberg RA, Rosenblatt M. A mouse model of human
breast cancer metastasis to human bone. Cancer
Research 2005; 65: 6130-6138. [Text]
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Bisello A, Chorev M, Rosenblatt
M, Monticelli L, Mierke DF, Ferrari SL. Selective
ligand-induced stabilization of active and desensitized
parathyroid hormone type 1 receptor conformations.
J Biol Chem 2002; 277: 38524-38530. [Text]
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Peggion E, Mammi S, Schievano
E, Silvestri L, Schiebler L, Bisello A, Rosenblatt
M, Chorev M. Structure-function studies of analogues
of parathyroid hormone (PTH)-1-34 containing _-amino
acid residues in positions 11-13. Biochemistry
2002; 41: 8162-8175.
[Text]
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Alexander J M, Bab I, Fish
S, Muller R, Uchiyama T, Gronowicz G, Nahounou
M, Zhao Q, White D W, Chorev M, Gazit D, and Rosenblatt
M. Human parathyroid hormone 1—34 reverses
bone loss in ovariectomized mice. J. Bone and Mineral
Research 2001; 16: 1665-1673.
[Text]
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Piserchio A, Bisello A, Rosenblatt
M, Chorev M, Mierke DF. Characterization of parathyroid
hormone/receptor interactions: structure of the
first extracellular loop. Biochemistry. 2000; 39:8153-8160.
[Text]
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Greenberg Z, Bisello A, Mierke
D F, Rosenblatt M, Chorev M. Mapping the bimolecular
interface of the parathyroid hormone (PTH)-PTH1
receptor complex: spatial proximity between Lys27
(of the hormone principal binding domain) and Leu261
(of the first extracellular loop) of the human
PTH1 receptor. Biochemistry 2000; 39:8142-8152.
[Text]
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| Behar V, Bisello A, Rosenblatt
M, Chorev M. Photoaffinity cross-linking identifies
differences in the interactions of an agonist and
an antagonist with the parathyroid hormone/parathyroid
hormone-related receptor. J Biol Chem 2000; 275:9-17. [Text] |
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Laboratory Information
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Principal Investigator
Michael Rosenblatt
Professor
Dean of Medical School
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Program Affiliations
Cellular & Molecular Physiology
Genetics
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Contact Information
Department of Physiology
Tufts University
136 Harrison Avenue
South Cove 8
Boston, MA 02111
Office (617) 636-6565
Lab (617) 636-3882
Fax (617) 636-0445
Send Email |
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