Daniela Bedenice
Assistant Professor
Department of Clinical Sciences
Large Animal Medicine
Phone: 508-839-7926
Fax: 508-839-7931
Email: daniela.bedenice@tufts.edu

Education
DVM - Free University of Berlin, Germany - 1997

Board Certification
Diplomate ACVIM (Large Animal)
Diplomate ACVECC

General Research Interest
Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid). Large Animal Neonatal Critical Care.

Research Sponsor Interest

• Privately Funded Research

Selected Research Projects

1. Non-invasive measurement of respiratory resistance (Rrs) using two different oscillatory methods in the horse: Comparative study of impulse oscillometry (IOS) and Monofrequency Forced Oscillatory Mechanics (FOM) in the adult horse, pre and post bronchodilation.

2. Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep. Veterinary Comparative Respiratory Society (VCRS), Boston, Massachusetts, September 2002.

3. Rapid non-invasive plethysmographic measurement of airway resistance (Raw) in awake dogs.

4. Respiratory mechanics in awake adult llamas.

Research and Clinical Interests

• Non-invasive pulmonary function testing (horse, dog, camelids)

• Comparative respiratory physiology

• Large Animal Neonatal Critical Care

• Advanced Medical Care for Equine and Camelid species (llama, alpaca)

Major Specialized Equipment Items Available
Pulmonary Mechanics Data Acquisition System - XA BioSystem ; Whole Body Plethysmograph (measurement of FRC); Canine (Head-Out) Plethysmograph (measurement of FRC, sRaw); small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography(Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software). video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.

Selected Publications

1. Bedenice D, Rozanski E, Bach J, Lofgren J and Hoffman AM. Canine awake head-out plethysmography (HOP): characterization of external resistive loading and spontaneous laryngeal paralysis. Resp Physiol Neurobiology, submitted August 2004.

2. Bedenice D, Bar-Yishay E, Ingenito E, Tsai L, Hoffman A. Head-out constant volume plethysmography for the non-invasive measurement of airway resistance [Raw] in conscious sheep. AJVR, 65(9):1259-1264, 2004.

3. Hoffman A, Kuehn H, Swanson L, Bedenice D. Pulmonary mechanics of saddle girth strapping in horses. AJVR, accepted 2004.

4. Dewitt SF, Bedenice D, Mazan M. Hemolysis, methemoglobinemia, and Heinz body formation associated with Red Maple leaf (Acer rubrum) ingestion in two alpacas. JAVMA, in press (2004).

5. Bedenice D, Heuwieser W, Solano M, Rand W, Paradis MR. Risk factors and prognostic variables for survival of foals with radiographic evidence of pulmonary disease. JACVIM, 17:868-875, 2003.

6. Bedenice D, Heuwieser W, Brawer R, Solano M, Rand W, Paradis MR. The clinical and prognostic significance of radiographic pattern, distribution and severity of thoracic radiographic changes in neonatal foals. JACVIM, 17:876-886, 2003.