Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications

Daniela Bedenice
Assistant Professor
Department of Clinical Sciences
Large Animal Medicine
Phone: 508-839-7926
Fax: 508-839-7931
Email: daniela.bedenice@tufts.edu

Education
Dr. med. vet. - Free University of Berlin, Germany - 1997

Board Certification
Diplomate ACVIM (Large Animal) - 2002
Diplomate ACVECC (Equine) - 2005

House Officer Training

Large Animal Internal Medicine

Clinical Interests

  • Large animal neonatal and adult cricital care
  • Camedlid internal medicine

Teaching

Equine neurology, gastro-intestinal disease, critical illness, acid base and goal-directed fluid therapy, clinical pharmacology (course director)

General Research Interest

  • Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid)
  • Large animal neonatal and adult critical care
  • Biological markers
  • Monitoring clinical pharmacology
  • Immunological function

Research Sponsor Interest

  • Privately Funded Research
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Selected Research Projects

  1. Hematological biomarkers in horses with enterocolitis
  2. Pharmacokinetics of florfenicol in alpacas
  3. Camelid heavy chain antibody-based antitoxins
  4. Characterization of immune responses in juvenile alpacas persistently infected with BVDV. Alpaca Research Foundation (ARF)
  5. The humoral response to EEE vaccination in healthy alpacas (ARF)
  6. Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep and dogs
  7. Respiratory mechanics in awake adult llamas and alpacas

Major Specialized Equipment Items Available

Thromboelastography, Pulmonary Mechanics Data Acquisition System - XA BioSystem; Whole Body Plethysmograph; Canine (Head-Out) Plethysmograph; small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography (Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software); video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.

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Selected Publications

  1. Pacheco A, Bedenice D, Mazan M, et al. Respiratory mechanics and BAL in healthy, adult alpacas. AJVR 2011 (in press).
  2. Holmes K, Bedenice D, Papick M. Florfenicol pharmacokinetics in healthy adult alpacas. JVPT 2011 (in press).
  3. Bedenice D, Dubovi E, Kelling CL. Long-term clinico-pathological characteristics of alpacas naturally infected with BVDV Type 16. JVIM 2011, 25(3);605-12.
  4. Vincent C, Hawley A, Rozanski E, Lascola K, Bedenice D. Cardiovascular effects of dobutamine and norepinephrine infusion in healthy, anesthetized alpacas. AJVR, under review 2008.
  5. Paxson JA, Cunningham S, Rush J, Bedenice D. "The effect of plasma volume expansion on cardio-vascular function in neonatal crias with PFT". JVECC, in press 2008.
  6. Bedenice D, Bright A, Pedersen D, Dibb J. "Humoral response to Equine Eastern Encephalitis vaccination in healthy alpacas". JAVMA, in press 2008.
  7. Bedenice D, Mazan MR, Hoffman AM. Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease. JVIM. 2008 Jul-Aug; 22(4):1022-8
  8. Bedenice D. Evidence-based medicine in equine critical care. Vet Clin North Am Equine Pract. 2007 Aug; 23(2):293-316.
  9. Bedenice D, Rozanski E., Bach J, Lofgren J. and Hoffman AM. Canine awake head-out plethysmography (HOP): characterization of external resistive loading and spontaneous laryngeal paralysis. Respir Physiol Neurobiol; 151(1):61-73, 2006.
  10. Bedenice D, Bar-Yishay E, Ingenito E, Tsai L, Hoffman A. "Head-out constant volume plethysmography for the non-invasive measurement of airway resistance [Raw] in conscious sheep". AJVR, 65(9):1259-1264, 2004.
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