Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Michael Court
Assistant Professor
Department of Biomedical Sciences
Pharmacology
Phone: 617-636-2741
Fax: 617-636-6738
Email: michael.court@tufts.edu
Personal URL: http://www.tufts.edu/~mcourt01/
Dept. URL: http://www.tufts.edu/med/about/programs/academicdepartments/physiologyandpharma/

Education
PhD - Tufts University - 2000
BS - University of Queensland - 1981

Board Certification
American College of Veterinary Anesthesiology

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Laboratory Personnel
Soundararajan Krishnaswamy, Research Associate
Leah Hesse, Postdoctoral Associate
Qin Hao, Research Technician
Abdul AlRohaimi, Graduate Student

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General Research Interest
Clinical Pharmacology, Drug Metabolism, Pharmacogenetics, Drug-Drug Interactions, UDP-glucuronosyltransferases, Intra- and Inter-species differences in drug metabolism.

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research
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Major Specialized Equipment Items Available

  • HPLC
  • HPLC-mass spec
  • Real-time PCR
  • cell culture
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Selected Publications

  1. Court MH and Greenblatt DJ: Molecular genetic basis for deficient glucuronidation of acetaminophen in cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms. Pharmacogenetics 10:355-369, 2000;

  2. Hay Kraus BL, Greenblatt DJ, Venkatakrishnan K and Court MH: Evidence for propofol hydroxylation by cytochrome P450 2B11 in canine liver microsomes: Breed and gender differences. Xenobiotica 30(6):575-588, 2000;

  3. Court MH, Duan SX, Guillemette C, Journault K, Krishnaswamy S, Von Moltke LL, Greenblatt DJ: Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos. 2002 Nov;30(11):1257-65;

  4. Court MH, Krishnaswamy S, Hao Q, Duan SX, Patten CJ, Von Moltke LL, Greenblatt DJ: Evaluation of 3\'-azido-3\'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. Drug Metab Dispos. 2003 Sep;31(9):1125-33. Web page of publications: http://www.tufts.edu/~mcourt01/publications.htm

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