Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications

Melissa R. Mazan
Associate Professor, Section Head of Large Animal Medicine & Surgery
Director of Equine Sports Medicine Program
Department of Clinical Sciences
Phone: 508-839-5395 ext. 84545
Fax: 508-839-7922
Email: melissa.mazan@tufts.edu

Education

DVM - Tufts University School of Veterinary Medicine - 1993
BA - Yale University - 1983

Teaching

  • Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
  • Equine sports medicine, equine exercise physiology, respiratory pathophysiology

Board Certification

  • American College of Veterinary Internal Medicine

General Research Interest

  • The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
  • Effects of particulate matter air pollution on equine respiratory disease
  • Resting energy in horses with recurrent airway obstruction
  • Non-invasive lung function testing
  • Stem cell applications in equine internal medicine
  • Role of the trophic macrophage in lung regeneration

Selected Publications

  1. Pacheco A, Bedenice D, Mazan M, Hoffman AM. Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas. Am J Vet Res 2012; Jan;73:146-152.
  2. Ingenito EP, Tsai L, Murthy S, Tyagi S, Mazan M, Hoffman A. Autologious lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant. 2012:21(1):175-189.
  3. Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, Ingenito EP, Hoffman AM. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myfibroblastic differentiation. PLoS One 2011:6(8):e23232.
  4. Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP. Lung derived mesenchymal stromal cell post-transplantaion survival, persistence, paracrine expression, and repair of elastase injured lung. Stem Cells Dev 2011;Oct:20(10)1779-1792.
  5. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, LAscola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP. Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 2010;298:L158-168. PMID 19915155.
  6. Paxson J, Parkin C, Iyer L, Mazan MR, Ingenito EP, and Hoffman AM. Global gene expression patterns during post-pneumonectomy lung regeneration in adult mice. Resp Res 2009:10:92. PMID 19804646.
  7. Nolen-Walston RD, Kuehn H, Boston RC, Mazan MR, Wilkins PA, Bruns S, Hoffman AM. Reproducibility of airway responsiveness in horses using flowmetric plethysmography and histamine bronchoprovocation. J Vet Intern Med 2009;23:631-635.
  8. Mazan MR, Merriam JG. Perspectives in Professional Education "A Description of the Tufts Cummings School of Veterinary Medicine" Massachusetts Equine Clinic Combined Equine Medicine Internship Program. JAVMA 2009, 235: 38-40.
  9. Mazan MR, Svatek J, Maranda L, Christiani D, Ghio A, Nadeau J, Hoffman AM. Questionnaire assessment of airway disease symptoms in equine barn personnel. Occup Med 2009;59(4):220-225.
  10. Ceresia ML, Fasser CE, Rush JE, Scheife RT, Orcutt CJ, Michalski DL, Mazan MR, Dorsey MT, Bernardi SP. The role and education of the veterinary pharmacist. Am J Pharm Educ. 2009;19:73:16.
  11. Nolen-Walston RD, Boston RC, Wilkins PA, Mazan MR, Kuehn H, Hoffman AM. Reproducibility of airway responsiveness using flowmetric plethysmography and histamine bronchoprovocation in horses. J Vet Int Med 2009:23;631-635.