Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Patrick Skelly
Associate Professor and Associate Chair
Department of Infectious Disease and Global Health
Phone: 508-887-4348
Fax: 508-839-7911
Email: patrick.skelly@tufts.edu
Dept. URL: http://www.tufts.edu/vet/dbs/infectious_diseases/
Lab URL: Molecular Helminthology Lab

Education
PhD - Australian National University, Canberra, Australia - 1986
BS - University College Dublin, Ireland - 1981

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General Research Interest
Parasitology, molecular and cellular helminthology

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research

Laboratory Personnel

 

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Selected Research Projects

  1. Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics. http://vet.tufts.edu/mhl/projects/schistosome.html

  2. Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.http://vet.tufts.edu/mhl/projects/schistosome.html

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Selected Publications

  1. Schistosome Na,K-ATPase as a therapeutic target. Da'dara AA, Faghiri Z, Krautz-Peterson G, Bhardwaj R, Skelly PJ. Trans R Soc Trop Med Hyg. 2013 Feb;107(2):74-82.

  2. Metabolite movement across the schistosome surface. Da'dara A, Krautz-Peterson G, Faghiri Z, Skelly PJ. J Helminthol. 2012 Jun;86(2):141-7.

  3. Schistosoma comparative genomics: integrating genome structure, parasite biology and anthelmintic discovery. Swain MT, Larkin DM, Caffrey CR, Davies SJ, Loukas A, Skelly PJ, Hoffmann KF. Trends Parasitol. 2011 Dec;27(12):555-64.

  4. Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Bhardwaj R, Krautz-Peterson G, Da'dara A, Tzipori S, Skelly PJ.
    Infect Immun. 2011 Oct;79(10):4276-84.

  5. Using RNA interference in Schistosoma mansoni. Bhardwaj R, Krautz-Peterson G, Skelly PJ. Methods Mol Biol. 2011;764:223-39.

  6. Manipulation of vascular function by blood flukes? Da'dara A, Skelly PJ. Blood Rev. 2011 Jul;25(4):175-9. doi: :10.1016/j.blre.2011.04.002.

  7. Characterization of schistosome tegumental alkaline phosphatase (SmAP). Bhardwaj R, Skelly PJ.
    PLoS Negl Trop Dis. 2011 Apr 5;5(4):e1011. PMID:21483710

  8. Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host. Krautz-Peterson G, Simoes M, Faghiri Z, Ndegwa D, Oliveira G, Shoemaker CB, Skelly PJ.
    PLoS Pathog. 2010 Jun 3;6(6):e1000932. PMID: 20532163

  9. The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: the surface aquaporin SmAQP is a lactate transporter. Faghiri Z, Camargo SM, Huggel K, Forster IC, Ndegwa D, Verrey F, Skelly PJ.
    PLoS One. 2010 May 3;5(5):e10451. PMID: 20454673

  10. RNA interference in schistosomes: machinery and methodology. Krautz-Peterson G, Bhardwaj R, Faghiri Z, Tararam CA, Skelly PJ. Parasitology. 2010 Mar;137(3):485-95. Epub 2009 Sep 21. PMID: 19765345

  11. Purinergic signaling and immune modulation at the schistosome surface? Bhardwaj R, Skelly PJ. Trends Parasitol. 2009 Jun;25(6):256-60. Epub 2009 May 5. PMID: 19423396

  12. The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake. Faghiri Z, Skelly PJ. FASEB J. 2009 Aug;23(8):2780-9. Epub 2009 Apr 13. PMID: 19364765

  13. Imaging schistosomes in vivo. Krautz-Peterson G, Ndegwa D, Vasquez K, Korideck H, Zhang J, Peterson JD, Skelly PJ. FASEB J. 2009 Aug;23(8):2673-80. Epub 2009 Apr 3. PMID: 19346298

  14. Fighting killer worms. Skelly P. Sci Am. 2008 May;298(5):94-9. PMID: 18444331

  15. Amino acid transport in schistosomes: Characterization of the permease heavy chain SPRM1hc. Krautz-Peterson G, Camargo S, Huggel K, Verrey F, Shoemaker CB, Skelly PJ. J Biol Chem. 2007 Jul 27;282(30):21767-75. Epub 2007 Jun 1. PMID: 17545149

  16. Optimizing gene suppression in schistosomes using RNA interference. Krautz-Peterson G, Radwanska M, Ndegwa D, Shoemaker CB, Skelly PJ. Mol Biochem Parasitol. 2007 Jun;153(2):194-202. Epub 2007 Mar 12. PMID: 17420062

  17. Sex and the Single Schistosome Skelly PJ.; Natural History. 2008; Jun;117(5):22-27
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