Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Patrick Skelly
Associate Professor
Department of Biomedical Sciences
Infectious Diseases
Phone: 508-887-4348
Fax: 508-839-7911
Email: patrick.skelly@tufts.edu
Dept. URL: http://www.tufts.edu/vet/biomed/infectious_diseases.htm
Lab URL: Molecular Helminthology Lab

Education
PhD - Australian National University, Canberra, Australia - 1986
BS - University College Dublin, Ireland - 1981

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General Research Interest
Parasitology, molecular and cellular helminthology

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research

Laboratory Personnel

  • Dr. Greice Krautz-Peterson, Research Associate
  • Dr. Zahra Faghiri, Postdoctoral Associate
  • Mr. David Mwai Ndegwa, Research Assistant
  • Ms. Rita Bhardwaj, Graduate Student

 

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Selected Research Projects

  1. Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics. http://www.tufts.edu/vet/helminthology/schistosome_projects.html

  2. Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.http://www.tufts.edu/vet/helminthology/schistosome_projects.html

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Selected Publications

  1. The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake. Faghiri Z, Skelly PJ. FASEB J. 2009 Apr 13.

  2. Imaging schistosomes in vivo. Krautz-Peterson G, Ndegwa D, Vasquez K, Korideck H, Zhang J, Peterson JD, Skelly PJ. FASEB J. 2009 Apr 3.

  3. Subversion of complement by hematophagous parasites. Schroeder H, Skelly PJ, Zipfel PF, Losson B, Vanderplasschen A. Dev Comp Immunol. 2009;33(1):5-13.

  4. Fighting Killer Worms. Skelly, PJ. Scientific American,  2008, May; 298(5): 72-77

  5. Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo. Krautz-Peterson G, Skelly PJ. Mol Biochem Parasitol. 2008 May;159(1):54-8.

  6. Protocols for gene silencing in schistosomes. Ndegwa D, Krautz-Peterson G, Skelly PJ. Exp Parasitol. 2007 Nov;117(3):284-91. Epub 2007 Aug 15.

  7. Amino acid transport in schistosomes: Characterization of the permease heavy chain SPRM1hc. Krautz-Peterson G, Camargo S, Huggel K, Verrey F, Shoemaker CB, Skelly PJ. J Biol Chem. 2007 Jul 27;282(30):21767-75.

     

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