Education | Laboratory Personnel | General Research Interest | Selected Research Projects
Research and Clinical Interests | Major Specialized Equipment Items Available | Selected Publications
TCSVM Faculty

Saul Tzipori
Distinguished Professor of Microbiology and Infectious Diseases
Agnes Varis University Chair in Science and Society
Director, Infectious Diseases
Phone: 508-839-7955
Fax: 508-839-7977
Email: saul.tzipori@tufts.edu
Dept. URL: http://www.tufts.edu/vet/biomed/infectious_diseases.htm

Education
FRCVS - Fellow Royal College of Veterinary Surgeons, London - 1990
DSc - University of Melbourne, Australia - 1985
Ph.D. - University of Queensland, Australia - 1974
DVM - (BVSc) - University of Queensland, Australia - 1970

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General Research Interest
Enteric infections and the host response; this includes viral, bacterial and protozoan pathogens of veterinary and medical importance causing acute or chronic diarrhea in the immunocompetent or the immunodeficient host. In recent years investigations have focused specifically on:

  1. The biology, pathogenesis, immunology, epidemiology, diagnosis, treatment, prevention and control of cryptosporidiosis and microsporidiosis in children from developing countries, and in individuals with HIV/AIDS;
  2. Mechanisms of disease caused by Shiga-toxin producing E. coli (STEC), and development of therapy against the associated hemolytic uremic syndrome (HUS) - a complicating acute kidney failure in children;
  3. Development of botulinum antitoxin therapy and control of intoxication in humans;
  4. Development of strategies for identification, characterization and risk assessment of food and waterborne pathogens.

Research Sponsor Interest

  • Privately Funded Research
  • Federally Funded Research
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Selected Research Projects

  1. Drug development for opportunistic infections-Cryptosporidium parvum

  2. Studies on Cryptosporidium parvum Type I

  3. Contribution of OIs to gut dysfunction & wasting in simian AIDS

  4. Construction of recombinant Stx-specific human antibodies

  5. Specific Human Monoclonal Antibodies for HUS Prophylaxis

  6. Role of intimin in tissue tropism and damage by EHEC

  7. Generation of Reagents for Enterocytozoon bieneusi Genome Sequencing

  8. Food and Waterborne Diseases Integrated Research Network

  9. Botulinum biology and development of antitoxin therapy

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Selected Publications

  1. Xu P, Widmer G, Wang Y, Ozaki LS, Alves JM, Serrano MG, Puiu D, Manque P, Akiyoshi D, Mackey AJ, Pearson WR, Dear PH, Bankier AT, Peterson DL, Abrahamsen MS, Kapur V, Tzipori S, Buck GA. The genome of Cryptosporidium hominis. Nature. 2004 Oct 28;431(7012):1107-12.

  2. Tzipori, S, Sheoran, A, Akiyoshi, D, Donohue-Rolfe, A, Trachtman, H. Antibody therapy in the management of shiga toxin-induced hemolytic uremic syndrome. Clin Microbiol Rev. 2004 Oct;17(4):926-41.

  3. Abrahamsen et al. Complete Genome Sequence of the Apicomplexan, Cryptosporidium parvum. Science. 2004;304:441-445.

  4. Okhuysen PC, Rogers GA, Crisanti A, Spano F, Huang DB, Chappell CL, Tzipori S. Antibody Response of Healthy Adults to Recombinant Thrombospondin-Related Adhesive Protein of Cryptosporidium 1 after Experimental Exposure to Cryptosporidium Oocysts. Clin Diagn Lab Immunol. 2004 Mar;11(2):235-238.

  5. Tumwine JK, Kekitiinwa A, Nabukeera N, Akiyoshi DE, Rich SM, Widmer G, Feng X, Tzipori S. Cryptosporidium parvum in children with diarrhea in Mulago Hospital, Kampala, Uganda. Am J Trop Med Hyg. 2003 Jun;68(6):710-5.

  6. Akiyoshi DE, Dilo J, Pearson C, Chapman S, Tumwine J, Tzipori S. Characterization of Cryptosporidium meleagridis of human origin passaged through different host species. Infect Immun. 2003 Apr;71(4):1828-32.

  7. Tumwine JK, Kekitiinwa A, Nabukeera N, Akiyoshi DE, Buckholt MA, Tzipori S. Enterocytozoon bieneusi among children with diarrhea attending Mulago Hospital in Uganda. Am J Trop Med Hyg. 2002 Sep;67(3):299-303.

  8. Akiyoshi DE, Mor S, Tzipori S. Rapid displacement of Cryptosporidium parvum type 1 by type 2 in mixed infections in piglets. Infect Immun. 2003 Oct;71(10):5765-71.

  9. Akiyoshi DE, Feng X, Buckholt MA, Widmer G, Tzipori S. Genetic analysis of a Cryptosporidium parvum human genotype 1 isolate passaged through different host species. Infect Immun. 2002 Oct;70(10):5670-5.

  10. Tzipori S, Ward H. Cryptosporidiosis: Biology, Pathogenesis and Disease. In Current Trends and Challenges Microbes Infect. 2002 Aug;4(10):1047-58.

  11. Sestak K, Ward LA, Sheoran A, Feng X, Akiyoshi DE, Ward HD, Tzipori S. Variability among Cryptosporidium parvum genotype 1 and 2 immunodominant surface glycoproteins. Parasite Immunology, 2002, 24:213-219.

  12. Okhuysen PC, Rich SM, Chappell CL, Grimes KA, Widmer G, Feng X, Tzipori S. Infectivity of a Cryptosporidium parvum isolate of cervine origin for healthy adults and interferon-gamma knockout mice. J Infect Dis. 2002 1;185(9):1320-5.

  13. Buckholt MA, Lee JH, Tzipori S. Prevalence of Enterocytozoon bieneusi in Swine: an 18-Month Survey at a Slaughterhouse in Massachusetts. Appl Environ Microbiol. 2002 May;68(5):2595-9.

  14. Mukherjee J, Chios K, Fishwild D, Hudson D, O'Donnell S, Rich SM, Donohue-Rolfe A, Tzipori S. Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection. Infect Immun. 2002 Feb;70(2):612-9.

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