Schistosome Publications

  1. Schroeder, H, Skelly, PJ Zipfel, PF, Losson, B, Vanderplasschen, A. Subversion of complement by hematophagous parasites. Dev. Comp. Imm., 2009; 33: 5–13.
  2. Skelly, PJ. Fighting Killer Worms. Scientific American, May 2008,Vol 298, No.5, 72-77
  3. Krautz-Peterson, G, Skelly PJ. Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo. Mol Biochem Parasitol 2008; 2008 May; 159(1):54-8.
  4. Skelly, PJ. Sex and the Single Schistosome. Natural History, June 2008, Vol 117, No.5, 22-27
  5. Sepulveda, J, Shoemaker, CB. 2008. Design and testing of PCR primers for the construction of scFv libraries representing the immunoglobulin repertoire of rats. J Immunol Methods. 332:92-102.
  6. Krautz-Peterson, G, Skelly, PJ. Schistosoma mansoni: The dicer gene and its expression. Exp Parasitol. 2007; Jan; 118(1):122-8.
  7. Ndegwa D, Krautz-Peterson, G, Skelly, PJ. Protocols for gene silencing in schistosomes. Exp Parasitol, 2007; 117(3), 284-291.
  8. Krautz-Peterson, G, Camargo, S, Huggel, K, Verrey, F, Shoemaker, CB, Skelly PJ. 2007. Amino acid transport in schistosomes: characterization of the permease heavy chain SPRM1hc. J. Biol. Chem. 282:21767-75.
  9. Krautz-Peterson, G, Radwanska, M, Ndegwa, D, Shoemaker, CB, Skelly, PJ. 2007. Optimizing gene suppression in schistosomes using RNA interference. Mol. Biochem. Parasitol. 153:194-202.
  10. Van Hellemond JJ, Retra K, Brouwers JFHM, van Balkom BWM, Yazdanbakhsh M, Shoemaker CB, Tielens, AGM. 2006. Functions of the tegument of schistosomes: clues from the proteome and lipidome. Int. J. Parasitol. 31:691-699.
  11. Skelly, PJ. Fighting killer worms. Scientific American, 2008; 298 (5): 94-99.
  12. Krautz-Peterson, G; Skelly, PJ. Schistosome asparaginyl > endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo. Mol Biochem Parasitol, 2008; 159 (1): 54-58.
  13. Skelly, PJ. Sex and the single schistosome. Natural History, 2008; 117 (5):22-27.
  14. Krautz-Peterson, G, Skelly, PJ. Schistosoma mansoni: The Dicer gene and its expression. Exp Parasitol, 2008; 118 (1): 122-128.
  15. Ndegwa D, Krautz-Peterson, G, and Skelly, PJ. Protocols for gene silencing in schistosomes. Exp Parasitol, 2007; 117(3), 284-291.
  16. Skelly PJ. 2005. The surface of schistosomes within the vertebrate host. Chapter 6 in "Schistosomiasis" Vol 10 in the World Class Parasite series. Secor, W. E., Colley, D. G. (Eds.). Kluwer Press.
  17. Skelly PJ. 2004. Intravascular schistosomes and complement. Trends Parasitol. 20, 370-4.
  18. Dalton JP, Skelly PJ and Halton DW. 2004. The role of the tegument and gut in the uptake of nutrients by parasitic platyhelminths. Can J Zool, 82, 211-232.
  19. Skelly PJ, Da'dara AA and Harn DA. 2003. Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. Int J Parasitol, 33, 363-9.
  20. Boyle, JP, Wu, X, Shoemaker, CB, Yoshino, TP. 2003. Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts. Mol. Biochem. Parasitol. 128:205-15.
  21. Da'dara AA Skelly PJ, Walker CM and Harn DA. 2003. A DNA-priming protein-boosting regimen significantly improves type 2 immune responses but not protective immunity to Schistosoma mansoni infection. Parasite Immunol, 25, 429-37.
  22. Da'dara AA, Skelly PJ, Fatakdawala M, Visocatti S, Eriksson E and Harn DA. 2002. Comparative efficacy of the Schistosoma mansoni nucleic acid vaccine, Sm23, following microseeding or gene gun delivery. Parasite Immunol, 24, 179-87.
  23. Da'dara A, Tsai MH, Tao LF, Marx KA, Shoemaker CB, Harn DA, Skelly PJ. 2001. Schistosoma mansoni: molecular characterization of a tegumental Ca-ATPase (SMA3). Exp Parasitol. 98:215-22.
  24. Skelly, PJ and Shoemaker, CB. 2001. Schistosoma mansoni proteases Sm31 (cathepsin B) and Sm32 (legumain) are expressed in the caecum and protonephridia of cercariae. J. Parasitol. 87:1218-21.
  25. El Ridi, R, Shoemaker, CB, Farouk, F, El Sherif, NH, and Afifi, A. 2001. Human T and B cell responses to Schistosoma mansoni recombinant glyceraldehyde 3-phosphate dehydrogenase correlate with resistance to reinfection with S. mansoni or S. haematobium after chemotherapy. Infect. Immun. 69:237-44.
  26. Skelly, PJ and Shoemaker, CB. 2001. The Schistosoma mansoni host interactive tegument forms from vesicle eruptions of a cyton network. Parasitology. 122:67-73.
  27. Skelly, PJ, Dougan, PM, Maule, A, Day, TA and Shoemaker, CB. 2001. Cloning and characterization of a muscle isoform of a Sodium Potassium ATPase alpha subunit (SNaK1) from Schistosoma mansoni. Parasitology. 123:277-84.
  28. Skelly, PJ and Shoemaker, CB. 2000. Induction cues for tegument formation during the transformation of Schistosoma mansoni cercariae. Int. J. Parasitol. 24:625-31.
  29. Skelly, PJ, Pfeiffer, R Verrey, F, and Shoemaker, CB. 1999. SPRM1lc a heterodimeric amino acid permease light chain of the human parasitic platyhelminth, Schistosoma mansoni. Parasitology. 119:569-576.
  30. Brouwers, JFHM, Skelly, PJ, Van Golde, LMG and Tielens, AGM. 1999. Studies on phospholipid turnover argue against sloughing of tegumental membranes in adult Schistosoma mansoni. Parasitology, 119, 287-94.
  31. El Ridi, R, Farouk, F, Sherif, M, Al-Sherminy, M, Osman, A, El Gengehi, N and Shoemaker, CB. 1998. T and B cell reactivity to a 42 kDa protein is associated with human resistance to both schistosomiasis mansoni and haematobium. J. Inf. Dis. 177:1364-72.
  32. Skelly, PJ, Tielens, AGM and Shoemaker, CB. 1998. Glucose transport and metabolism in mammalian stage schistosomes. Parasitol. Today. 14:402-406.
  33. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, PJ, Shoemaker, C and Verrey, F. 1998 Amino acid transport by heterodimers of 4F2/CD98 and members of a permease family. Nature, 395, 288-92.
  34. Davies, SJ, Shoemaker, CB and Pearce, EJ. 1998. A divergent member of the transforming growth factor b receptor family from Schistosoma mansoni is expressed on the parasite surface membrane. J. Biol. Chem. 273:11234-40.
  35. Skelly, PJ and Shoemaker, CB. 1996. Rapid Appearance and Asymmetric Distribution of Glucose Transporter, SGTP4, at the Apical Surface of Intramammalian Stage Schistosoma mansoni. Proc. Natl. Acad. Sci. USA.93:3642-3646.
  36. Jiang, J, Skelly, PJ, Shoemaker, CB and Caulfield, JP. 1996. Schistosoma mansoni: The glucose transport protein SGTP4 is present in the tegumental multilamellar bodies, discoid bodies, and the surface lipid bilayers. Exp. Parasitol. 82:201-210.
  37. Armstrong, RL, Wilson, JE and Shoemaker, CB. 1996. Purification and characterization of the hexokinase from Schistosoma mansoni, expressed in E. coli. Prot. Expr. and Purif. 8:374-380.
  38. Ramachandran, H, Skelly, PJ and Shoemaker, CB. 1996. The Schistosoma mansoni epidermal growth factor receptor homologue, SER, has tyrosine kinase activity and is localized in adult muscle. Mol. Biol. Parasitol. 83:1-10.
  39. Shoemaker CB, Reynolds S, Wei G, Tielens, AGM, Harn D. 1995. Schistosoma mansoni hexokinase: cDNA cloning and immunogenicity studies. Exp. Parasitol. 80:36-45.
  40. Zhong, C, Skelly, PJ, Leaffer, D, Cohn, RL, Caulfield, JP and Shoemaker, CB. 1995. Immunolocalization of a Schistosoma mansoni facilitated glucose transporter to the basal, but not the apical membranes of the surface syncytium. Parasitology. 110:383-394.
  41. Skelly PJ and Shoemaker, CB. 1995. A molecular genetic study of the variations in metabolic function during schistosome development. Mem. do Inst. Osw. Cruz. 90:281-284.
  42. Laclette, JP, Skelly, PJ, Merchant, MT, Shoemaker, CB. 1995. Aldehyde fixation dramatically alters the immunolocalization pattern of paramyosin in platyhelminth parasites. Exp. Parasitol. 81:140-143.
  43. Skelly PJ, Kim, JW, Cunningham J, Shoemaker, CB. 1994. Cloning, characterization and functional expression of cDNAs encoding glucose transporter proteins from the human parasite, Schistosoma mansoni. J. Biol. Chem. 269:4247-4253.
  44. Bosch IB, Wang XZ, Shoemaker CB. 1994. Two Schistosoma mansoni cDNAs encoding ATP cassette (ABC) family proteins. Mol. Biochem. Parasitol. 65:351-356.
  45. Skelly PJ, Secor WE, Reis MG, Ramos EA, Carmo TM, Reis EA and Harn DA. 1994. Failure of schistosomiasis to significantly decrease testosterone levels in Brazilian men. Am J Trop Med Hyg, 51(1), 40-4.
  46. Shoemaker, CB. 1994. Schistosoma mansoni phosphagen kinase gene contains two closely apposed transcription initiation sites and arose from a fused gene duplication. Mol. Biochem. Parasitol. 68:319-322.
  47. Tielens, AGM, van den Heuvel, JM, van Mazijk, HJ, Wilson, J and Shoemaker, CB. 1994. The 50-kDA, glucose-6-phosphate sensitive hexokinase of Schistosoma mansoni, enzymatic properties and amino- acid sequence analysis. J. Biol. Chem. 269:24736-24741.
  48. dos Reis MG, Davis RE, Singh H, Skelly PJ, Shoemaker CB. 1993. Characterization of the Schistosoma mansoni gene encoding the glycolytic enzyme, triose phosphate isomerase. Mol. Biochem. Parasitol. 59:235-242.
  49. Skelly PJ, Stein L, Shoemaker CB. 1993. Expression of Schistosoma mansoni Genes Involved in Anaerobic and Oxidative Glucose Metabolism During the Cercarial to Adult Transformation. Mol. Biochem. Parasitol. 60:93-104.
  50. Shoemaker CB, Gross A, Gebremichael A, Harn D. 1992. cDNA cloning and functional expression of the Schistosoma mansoni protective antigen, triose phosphate isomerase. Proc. Natl. Acad. Sci. USA. 89:1842-1846.
  51. Shoemaker CB., Ramachandran H, Landa A, Reis M, Stein L. 1992. Alternate splicing of the Schistosoma mansoni gene encoding a homologue of epidermal growth factor receptor. Mol. Biochem. Parasitol. 53:17-32.
  52. Reynolds SR, Shoemaker CB, Harn DA. 1992. T and B cell epitope mapping of SM23, an integral membrane protein of Schistosoma mansoni. J. Immunol. 149:3995-4001.
  53. Laclette JP, Landa A, Arcos L, Willms K, Davis E, Shoemaker CB. 1991. Paramyosin is the Schistosoma mansoni (trematoda) homologue of antigen B from Taenia solium (cestoda). Mol. Biochem. Parasitol 44:287-296