Articles

Lens with Developing Cataract

142. Chiu, C-J, Milton, R.C., Klein, R., Gensler, G., And Taylor, A. Diet, supplement and risk of age-related macular degeneration in the Age-Related Eye Disease Study. Manuscript submitted.

141. Jacques, P., et al Taylor, A. Effect of nutrients on change in early lens nuclear opacity grades after five years. Manuscript submitted.

140. Moeller, S. et al Taylor, A. Relations between nutrient intake and risk for early Age Related Maculopathy in the Nutrition and Vision Project. Manuscript in preparation

139. Morris, M. S. Jacques, P. F., Hankinson, S.E., Chylack, L. T. Willett, W. C. and Taylor, A. Nuclear and cortical opacities in relation to alcoholic beverage consumption. Manuscript submitted

138. Guo, W. Shang, W., And Taylor, A. Regulation of proliferation and differentiation of the lens epithelium by the ubiquitin proteasome pathway. Manuscript in preparation.

137. Liu, Q., Shang, F., Hobbs, M., Valverde, P., Reddy, V., and Taylor, A. Regulation of the human lens epithelial cell cycle at G2M by ubiquitin conjugating enzyme 3. Manuscript in preparation.

136. Lu, M., Chylack, LT, Taylor, A., Hankinson, SE, Willett, WC, Jacques, PF. Dietary fat intake and progress of early age-related lens nuclear opacites over 5 years. Manuscript in preparation.

135. Guo, W. Shang, W., And Taylor, A. Regulation of proliferation and differentiation of the lens epithelium by the ubiquitin proteasome pathway. Manuscript in preparation.

134. Liu, Q., Shang, F., Hobbs, M., Valverde, P., Reddy, V., and Taylor, A. Regulation of the human lens epithelial cell cycle at G2M by ubiquitin conjugating enzyme 3. Manuscript in preparation.

133. Chiu, C.J., Milton, R.C., Ferris III, F.L., Gensler, G., and Taylor, A. Dietary Carbohydrate and glycemic index in relation to Age-Related Macular Degeneration - The Age-Related Eye Disease Study. manuscript submitted.

132. Lu, M., Taylor, A., Chylack, LT, Hankinson, SE, Willett, WC, Jacques, PF. Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. J Am Coll Nutr. 2007 Apr;26(2):133-40

131. Liu, Q., Shang, F., Zhang, X., Li, W., Taylor, A., Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells. Mol. Vis. (2006) 12, 931-6.

130. Fernandes, AF., Guo, W, Zhang, X., Gallagher, M., Ivan, M., Taylor, A., Pereira, P. and Shang, F Proteasome-Dependent Regulation Of Signal Transduction In Retinal Pigment Epithelial Cells, Invest. Exp Eye Res. (2006), ;83, 1472-81

129. Zetterberg, M ., Zhang, X ., Taylor, A., Liu, B ., Liang J.J ., Shang, F . Glutathiolation enhances the degradation of {gamma}C-crystallin in lens and reticulocyte lysates, partially via the ubiquitin-proteasome pathway. Invest Ophthalmol Vis Sci. (2006);47, 3467-73

128. Shang, F., Dudek, E., Liu, Q., Boulton, M., Taylor, A. Protein Quality Control by the Ubiquitin Proteolytic Pathway: roles in resistance to oxidative stress and disease. Is. J. Chem. (2006) 46, 145-158.

127. Morris, M.S., Jacques, P.F., Chylack, L.T., Hubbard, L.D., Armstrong, J., Hankinson, S.E., Willett, W.C., Taylor, A. Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions. (In Press)

126. Moeller, S., Tucker, K.L., McCullough, M.L., Rogers, G., Chylack, L.T., Taylor, A. Hankinson, S.E., Willett, W.C., Jacques, P.F. Diet Quality and change in early age-related nuclear lens opacities. manuscript submitted.

125. Chiu, C-J., P. F. Jacques, G. Rogers, L.T. Jr. Chylack, S. E. Hankinson, W. C. Willett, and Taylor, A. Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration. (2006) 83, 880-6.

124. Chiu, C.J., Milton, R.C., Ferris III, F.L., Gensler, G., and Taylor, A. Dietary carbohydrate and glycemic index in relation to cortical and nuclear lens opacities - The Age-Related Eye Disease Study. Am. J. Clin. Nut. (2006) 83, 1177-84.

123. Chiu, C-J., Morris, M. S. Jacques, P. F., Hankinson, S.E., Chylack, L. T. Willett, W. C. and Taylor, A. Dietary carbohydrate intake and glycemic index in relation to cortical and nuclear lens opacities in the Age-Related Eye Disease Study. Am J Clin Nutr (2006) 83, 1177-84.

122. Guo, W., Shang, F., Liu, Q., Urim, L., Zhang, M., and Taylor, A. Ubiquitin-Proteasome pathway function is required for lens cell proliferation and differentiation. Invest Ophthalmol. Vis. Sci. (2006) 47, 2569-75.

121. Liu, Q., Shang, F., Whitcomb, E., Guo, W., Li, W., and Taylor, A. Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase. Invest Ophthalmol. Vis. Sci. (2006) 47, 1302-9.

120. Chiu, C-J, Klintworth, G,K., and Taylor, A (2006) Nutritional deficiencies and excesses in relation to risk for age-related macular degeneration and cataract in Vitamin Deficiencies and Excesses (G. K. Klintworth ed) in press

119. Chiu, C-J., Seddon, J. and Taylor, A (2006) Antioxidant Supplements and Age-Related Macular Degeneration. Medscape

118. Marques, C., Guo, W., Pereira, P., Taylor, A., Patterson, C., Evans, P.C., Shang, F. The triage of damaged proteins: Degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J. (2006) 10.1096/fj.05-5080fje. 20(6):741-3.

117. Shang F, Deng G, Liu Q, Guo W, Haas AL, Crosas B, Finley D, Taylor A. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem 2005;280(21):20365-20374.

116. Siegal M, Chiu CJ, Taylor A. Antioxidant status and risk for cataract. In: Preventive Nutrition: A Comprehensive Guide for Health Professionals.Totowa, NJ: Humana Press, 2005:463-504.

115. Dudek, E., Shang, F., Q. Liu, Q., Hobbs, M., and Taylor A. Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases (2005) 19, 1707-9.

114. Shang, F., Deng, G., Liu, Q., Guo, W., R., Haas, A.L., Crosas, B., Finley, D., and Taylor, A. Lys6-Modified Ubiquitin Inhibits Ubiquitin-Dependent Protein Degradation J. Biol. Chem. (2005) 280, 20365-74.

113. Chiu, C-J., G. Rogers, M. S. Morris, P. F. Jacques, L.T. Jr. Chylack, S. E. Hankinson, W. C. Willett, and Taylor, A. Long-term dietary carbohydrate intake, glycemic index and odds for early nuclear and cortical lens opacities. Am. J. Clin. Nut. (2005) 81,1411-6.

112. Lu, M., Cho, E., Taylor, A., Hankinson, SE, Willett, WC, Chylack LT, Jacques, PF. Prospective study of dietary fat and risk of cataract extraction among US Women. Am. J. Epi. (2005) 161 (10): 948-59.

111. Lu, M., Taylor, A., Chylack, LT, SE, Willett, WC, Jacques, PF. Dietary fat intake and early age-related lens opacities. Am. J. Clin. Nut. (2005) 81, 773-9.

110. Dudek, E., Shang, F., Q. Liu, Q., Hobbs, M., and Taylor A. Selectivity of the Ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation disease- FASEB J (2005) 19, 1707-9.

109. Jacques, P., Taylor, A., Moeller, S., Hankinson, S.E., Rogers, G., Tung, W., Ludovico, J., Willett, W.C., Chylack, L.T. Long-term nutrient intake and five-year change in nuclear opacities. Arch. Ophthalmol. (2005) 123, 517-26.

108. Girao, H., Pereira, P., Taylor, A. and Shang, F. Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation. Invest. Opth. Vis. Sci. (2005) 46, 1386-92.

107. Moeller, S. et al Taylor, A. Tucker, K.L., McCullough, M.L., Chylack, L.T., Hankinson, S.E., Willett, W.C., Jacques, P.F. Overall Adherence to the Dietary Guidelines for Americans is Associated with Reduced Prevalence of Early Age-Related Nuclear Lens Opacities in Women J. Nutr. (2004) 134, 1812-9.

106. Morris, M.S. Jacques, P.F., Hankinson, S.E., Chylack, L.T. Willett, W.C. and Taylor, A. Moderate alcoholic beverage intake and early nuclear and cortical opacities. Ophthalmic Epidemiol. (2004) 11, 53-65.

105. Girão, H., Pereira, P., Taylor, A. and Shang, F. (2004) Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation. Submitted to Invest Ophthalmol. Vis. Sci.

104. Taylor, A. Is Hyperleptinemia involved in the development of age-related lens opacities? Am. J. Clin. Nut. (2004) 889.

103. Shang, F. and Taylor, A. Function of the Ubiquitin Proteolytic Pathway in the Eye. Exp. Eye Res. (2004) 78, 1-14.

102. Guo, W., Shang, F., Urim, L., West-Mays, J., Zelenka, P., and Taylor, A. Differential Regulation of Components of the Ubiquitin-Proteasome Pathway During Lens Cell Differentiation. Invest Ophthalmol. Vis. Sci. (2004) 4, 1194 - 1201.

101. Valverde, P., Obin, M.S., and Taylor, A. Role of Gas6/Axl Signaling in Lens Epithelial Cell Proliferation and Survival. Exp. Eye Res. (2004) 78, 27-37.

100. Liu, Q., Shang, F., Hobbs, M., Valverde, P., Reddy, V., and Taylor, A. Regulation of the Ubiquitin Proteasome Pathway in Human Lens Epithelial Cells During Cell Cycle. Exp. Eye Res. Exp. Eye Res. (2004) 78, 197-205.

99. Marques, C., Perriera, P., Taylor, A, Reddy, V. N., Szweda, L.I., and Shang, F. Ubiquitin-Dependent Lysosomal Degradation of the HNE-Modified Proteins in Lens Epithelial Cells. FASEB J. (2004) 12, 1424-6.

98. Jacques, P., et al Taylor, A. Abdominal adiposity, diabetes and early age-related lens opacities. Am. J. Clin. Nut. (2003) 78, 400-405

97. Pereira, P. Shang, F. Hobbs, M., Girao, H., and Taylor, A. The eye lens has a fully functional ubiquitin pathway. Exp Eye Res (2003) 76, 623 31

96. Shang, F, Lu, M., Dudek, E., Reddan, J. and Taylor, A. Vitamin C and Vitamin E Restore the Resistance of Glutathione-depleted Lens Epithelial Cells to Peroxide J. Free Rad. Res. (2003) 34, 521-530.

95. Shang, F., Gong, X., Egtesadi, S., Meydani, M., Smith, D., Perrone, G., Scott, L., Blumberg, J. B., and Taylor, A. Vitamin C prevents hyperbaric oxygen-induced growth retardation and lipid peroxidation and attenuates the oxidation-induced up-regulation of glutathione in guinea pigs. J. Nutr. Biochem. (2002) 13, 307-313.

94. Weintraub, J.M., Taylor, A., Jacques, P., Willett, W.C., Rosner, B., Colditz, G.A., Chylack, L.T., Jr., and Hankinson, S.E. Postmenopausal hormone use and lens opacities. Ophthalmic Epidemiol. (2002) 9, 179-190.

93. Taylor, A., Jacques, P.F., Chylack, L.T., Jr. Hankinson, S.E. Khu, P.M., Rogers, G., Friend, J., Tung, W., Wolfe, J.K., Padhye, N., and Willett, W.C. Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. Am. J. Clin. Nutr. (2002) 75, 540-549.

92. Hao, W., Wenzel, A., Obin, M.S., Chen, C-K., Brill, E., Krasnoperova, N.V., Eversole-Cire, P., Kleyner, Y., Taylor, A., Simon, M.I., Grimm, C., Reme, C.E., and Lem, J. Evidence for Two Apoptotic Pathways in light-Induced Retinal Degenerations. Nature Genetics (2002) 32, 254-60.

91. Obin, Y., Lee, B.Y., Meinke, G., Bohm, A., Lee, R.H., Gaudet, R., Hopp, J.A., Arshavsky, V.Y., Willardson, B.M., and. Taylor, A. Ubiquitilyation of the Transducin beta-gamma Subunit Complex: Regulation by Phosducin. J. Biol. Chem. (2002) 277, 44566-75.

90. Shang, F., Nowell, T., Gong, X., Smith, D.E., Dallal, G.E., and Taylor, A. Sex-linked differences in Cataract Progression in Emory Mice. Exp. Eye Res. (2002) 75, 109-111.

89. Taylor, A. Shang, F. , Nowell, T., Galanty, Y, Shiloh, Y. Ubiquitination capabilities in response to stress in A-T and wild type lymphoblasts. Oncogene (2002) 21 4363-73.

88. Shang, F., Deng, G., Wu, C.N., Gong, X., Nowell, T.R., Jr., Smith, D., Laursen, R.A., and Taylor, A. The origin of the two isoforms of ubiquitin-activating enzyme(E1) Exp. Eye Res. (2001) 73, 827-836.

87. Dudek, E., Shang, F., Taylor, A. H2O2-mediated oxidative stress activates NF-kB while decreasing nuclear AP-1 DNA-binding in lens epithelial cells. Free Rad. Biol. Med. (2001) 31, 651-658.

86. Shang, F., Nowell, T. Jr., Taylor, A., Removal of oxidatively damaged proteins from lens cells by the ubiquitin-proteasome pathway. Exp. Eye Res. (2001) 73, 229-238.

85. Stramer, B.M., Cook, J.R., Fini, M.E., Taylor, A., Obin, M. Induction of the ubiquitin-proteasome pathway during the keratocyte transition to the repair fibroblast phenotype. Invest. Ophthalmol. and Vis. Sci (2001) 42, 1698-1706.

84. Jacques, P.F., Chylack, L.T., Jr., Hankinson, S.E., Khu, P.M., Rogers, G., Friend, J., Tung, W., Wolfe, J.K., Padhye, N., Willett, W.C., and Taylor, A. Long-term nutrient intake and early age-related nuclear lens opacities. Arch. Ophthalmol. (2001) 119, 1009-1019.

83. Taylor, A. and Moeller, S. Fat cat(aract). Am. J. Clin. Nutr. (2000) 72, 1417-8.

82. Tofler, G.H., Stec, J.J., Stubbe, I., Beadle, J., Feng, D., Lipinska, I., and Taylor, A. The effect of vitamin C supplementation on coagulability and lipid levels in healthy male subjects. Thromb. Res. (2000) 100, 35-41.

81. Obin, M., Pike, A., Halbleib, M., Lipman, R., Taylor, A., and Bronson, R. Calorie restriction modulates age-dependent changes in the retinas of Brown Norway rats. Mech. Ageing Develop. (2000) 114, 133-147.

80. Obin, M., Halbleib, M., Lipman, R., Carroll, K., Taylor, A., and Bronson, R. Calorie restriction increases light-dependent photoreceptor cell loss in the neural retina of Fischer 344 rats. Neurobiology of Aging. (2000) 21, 639-645.

79. Yeum, K.-J., Shang, F., Schalch, W., Russell, R.M., and Taylor, A. Fat-soluble nutrient concentrations in different layers of human lens. Curr. Eye Res. (1999) 19, 502-505.

78. Smith, D., Shang, F., Nowell, T.R., Jr., Asmundsson, G., Perrone, G., Dallal, G., Scott, L., Kelliher, M., Gindelsky, B., and Taylor, A. Decreasing ascorbate intake does not affect the levels of glutathione, tocopherol or retinol in the ascorbate-requiring osteogenic disorder Shionogi rats. J. Nutr. (1999) 129, 1229-1232.

77. Obin, M., Mesco, E., Gong, X., Haas, A., Joseph, J., Taylor, A. Neurite outgrowth in PC12 cells: Distinguishing the roles of ubiquitylation and ubiquitin-dependent proteolysis. J. Biol. Chem. (1999) 274, 11789-11795.

76. Shang, F., Gong, X., McAvoy, J.W., Chamberlain, C., Pickart, C.M., Nowell, Jr., T.R., and Taylor, A. Ubiquitin-dependent pathway is up-regulated in differentiating lens cells. Exp. Eye Res. (1999) 68, 179-192.

75. Scrofano, M.M., Jahngen-Hodge, J., Nowell, Jr., T.R., Gong, X., Smith, D.E., Perrone, G., Asmundsson, G., Gindlesky, B., Mura, C.V., and Taylor, A. The effects of aging and calorie restriction on plasma nutrient levels in male and female Emory mice. Mech. Ageing Dev. (1998), 105, 31-44.

74. Scrofano, M.M., Shang, F., Nowell, Jr., T.R., Gong, X., Smith, D.E., Kelliher, M., Dunning, J., Mura, C.V., and Taylor, A. Aging, calorie restriction and ubiquitin-dependent proteolysis in the livers of Emory mice. Mech. Ageing Dev. (1998), 101, 277-296.

73. Scrofano, M.M., Shang, F., Nowell, Jr., T.R., Gong, X., Smith, D.E., Kelliher, M., Dunning, J., Mura, C.V., and Taylor, A. Calorie restriction, stress and the ubiquitin-dependent pathway in mouse livers. Mech. Ageing Dev. (1998) 105, 273-290.

72. Obin, M., Shang, F., Gong, X., Handelman, G., Blumberg, J., and Taylor, A. Redox regulation of ubiquitin-conjugating enzymes: mechanistic insights using the thiol-specific oxidant diamide. FASEB J., (1998) 12, 561-569.

71. Taylor, A. Etiology and influences of nutrition on risk for cataract. Molecular Aspects of Medicine (1997) 18, 353-378.

70. Shang, F., and Taylor, A. Oxidation and protein degradation in the lens. Molecular Aspects of Medicine (1997) 18, 339-352.

69. Shang, F., and Taylor, A. Protein modification in the lens upon aging and cataractogenesis. Molecular Aspects of Medicine (1997) 18, 331-338.

68. Obin, M.S., and Taylor, A. Selective proteolysis in photoreceptor function and disease. Molecular Aspects of Medicine (1997) 18, 309-330.

67. Gong, X., Shang, F., Obin, M.S., Palmer, H., Scrofano, M., Jahngen-Hodge, J., Smith, D., and Taylor, A. Antioxidant enzyme activities in lens, liver and kidney of calorie-restricted Emory mice. Mech. Ageing Dev. (1997), 99, 181-193.

66. Jahngen-Hodge, J., Obin, M. S., Nowell, T. R., Jr., Gong, J., Abasi, H., Blumberg, J., and Taylor, A. Regulation of ubiquitin conjugating enzymes by glutathione following oxidative stress. J. Biol. Chem. (1997) 272, 28218-28226.

65. Jacques, P.F., Taylor, A., Hankinson, S.E., Lahav, M., Mahnken, B., Lee, Y., Vaid, K., and Willett, W. Long-term vitamin C supplement use and prevalence of newly diagnosed age-related lens opacities. Am. J. Clin. Nutr. (1997) 66, 911-916.

64. Taylor, A., Jacques, P., Nowell, T., Jr., Perrone, G., Nadler, D., and Joswiak, B. Vitamin C in human and guinea pig aqueous, lens, and plasma in relation to intake. Curr. Eye Res. (1997) 16, 857-864.

63. Shang, F., Gong, X., and Taylor, A. Activity of ubiquitin-dependent pathway in response to oxidative stress: Ubiquitin-activating enzyme is transiently upregulated. J. Biol. Chem. (1997) 272, 23086-23093.

62. Shang, F., Gong, X., Palmer, H., Nowell, T., and Taylor, A. Age-related decline in ubiquitin conjugation in response to oxidative stresses in the lens. Exp. Eye Res. (1997) 64, 21-30.

61. Mura, C.V., Gong, X., Taylor, A., Villalobos-Molina, R., and Scrofano, M. Effects of calorie restriction and aging on the expression of antioxidant enzymes and ubiquitin in the liver of Emory mice. Free Radic. Biol. Med. (1996), 91:115-129.

60. Obin, M.S., Jahngen-Hodge, J., Nowell, T., and Taylor, A. Ubiquitinylation and ubiquitin-dependent proteolysis in vertebrate photoreceptors (rod outer segments): evidence for ubiquitinylation of Gt and rhodopsin. J. Biol. Chem. (1996) 271:14473-14484.

59. Yeum, K.-J., Taylor, A., Tang, G., and Russell R.M. Measurement of carotenoids, retinoids and tocopherols in human lenses. Invest. Ophthalmol. Vis. Sci. (1995) 36:2756-2761.

58. Mune, M., Meydani, M., Janhgen-Hodge, J., Martin, A., Smith, D., Palmer, V., Blumberg, J.B., and Taylor, A. Effect of calorie restriction on liver and kidney glutathione in aging Emory mice. AGE (1995) 18:43-49.

57. Taylor, A., and Jacques, P.F. Relationships between aging, antioxidant status, and cataract. Am. J. Clinical Nutr. (1995) 62:1439S-1447S.

56. Obin, M., Nowell, T., and Taylor, A. A comparison of ubiquitin-dependent proteolysis of rod outer segment proteins in reticulocyte lysate and a retinal pigment epithelial cell line. Curr. Eye Res. (1995), 14:751-760.

55. Huang, L.L., Shang, F., and Taylor, A. Degradation of differentially oxidized a-crystallins in bovine lens epithelial cells. Exp. Eye Res. (1995) 61:45-54.

54. Taylor, A., Jahngen-Hodge, J., Smith, D., Palmer, V., Dallal, G., Lipman, R., Padhye, N., and Frei, B. Dietary restriction delays cataract and reduces ascorbate levels in Emory mice. Exp. Eye Res. (1995) 61:55-62.

53. Shang, F., and Taylor, A. Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells. Biochem. J. (1995) 307:297-303.

52. Taylor, A., Lipman, R.D., Jahngen-Hodge, J., Palmer, V., Smith, D., Padhye, N., Dallal, G.E., Cyr, D.E., Laxman, E., Shepard, D., Morrow, F., Solomon, R., Perrone, G., Asmundsson, G., Meydani, M., Mune, M., Harrison, D., and Archer, J. Dietary calorie restriction in the Emory Mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity and cancer. Mech. Ageing Dev. (1995) 79:33-57.

51. Meydani, M., Martin, A., Sastre, J., Smith, D., Dallal, G., Taylor, A., and Blumberg, J. Dose-response characteristics of galactose-induced cataract in the rat. Ophthalmic Res. (1994) 26:368-374.

50. Sastre, J., Meydani, M., Martin, A., Biddle, L., Taylor, A., and Blumberg, J. Effect of glutathione monoethyl ester administration on galactose-induced cataract in the rat. Life Chemistry Reports (1994) 12:89-95.

49. Shang, F., Huang, L.L., and Taylor, A. Degradation of native and oxidized beta- and gamma-crystallin using bovine lens epithelial cell and rabbit reticulocyte extracts. Curr. Eye Res. (1994) 13:423-431.

48. Obin, M.S., Nowell, T., and Taylor, A. The photoreceptor G-protein transducin (Gt) is a substrate for ubiquitin-dependent proteolysis. Biochem. Biophys. Res. Comm. (1994) 200:1169-1176.

47. Mura, C.V., Roh, S., Smith, D., Palmer, V., Padhye, N., and Taylor, A. Cataract incidence and analysis of lens crystallins in the water- , urea- , and SDS-soluble fractions of Emory mice fed a diet restricted by 40% in calories. Curr. Eye Res. (1993) 12:1081-1091.

46. Wallner, B.P., Hession, C., Tizard, R., Frey, A.Z., Zuliani, A., and Taylor, A. Isolation of bovine kidney leucine aminopeptidase cDNA: Comparison with the lens enzyme and tissue-specific expression of two mRNAs. Biochemistry (1993) 32:9296-9301.

45. Taylor, A. Aminopeptidases: toward a mechanism of action. TIBS (1993) 18:167-172.

44. Taylor, A. Cataract: relationships between nutrition and oxidation. J. Am. Coll. of Nutr. (1993) 12:138-146.

43. Smith, D., Palmer, V., Kehayias, J., and Taylor, A. Induction of cataracts by x-ray exposure of guinea pigs eyes. Lab Animal (1993) 22:34-39.

42. Taylor, A. Aminopeptidases: structure and function. FASEB J. (1993) 7:290-298.

41. Taylor, A., Peltier, C.Z., Torre, F.J., and Hakamian, N. Inhibition of bovine lens leucine aminopeptidases by bestatin: number of binding sites and slow binding of this inhibitor. Biochemistry (1993) 32:784-790.

40. Huang, L.L., Jahngen-Hodge, J., and Taylor, A. Bovine lens epithelial cells have a ubiquitin-dependent proteolysis system. Biochim. Biophys. Acta (1993) 1175:181-187.

39. Taylor, A., Smith, D.E., Palmer, V.J., Shepard, D., Padhye, N., Theriault, C., and Morrow, F. Relationships between acetone, cataracts, and ascorbate in hairless guinea pigs. Ophthalmic Research (1993) 25:30-35.

38. Jahngen-Hodge, J., Cyr, D., Laxman, E., and Taylor, A. Ubiquitin and ubiquitin conjugates in human lens. Exp. Eye Res. (1992) 55:897-902.

37. Taylor, A., Jacques, P.F., and Dorey, D. K. Oxidation and aging: Impact on vision. J. Toxicol. Indust. Health. (1992) 9:349-371.

36. Taylor, A., Peltier, C.Z., Jahngen, E.G.E., Jr., Laxman, E., and Torre, F.J. Use of azidobestatin as a photoaffinity label to identify the active site peptide of leucine aminopeptidase. Biochemistry (1992) 31:4141-4150.

35. Harris, C.A., Hunte-McDonough, B., Krauss, M.R., Taylor, A., and Epstein, L.B. Induction of leucine aminopeptidase by interferon gamma identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis. J. Biol. Chem. (1992) 267:6865-6869.

34. Burley, S.K., David, P.R., Sweet, R.M., Taylor, A., and Lipscomb, W.N. Structure determination and refinement of bovine lens leucine aminopeptidase and its complex with bestatin. J. Mol. Biol. (1992) 224:113-140.

33. Taylor, A., Jahngen-Hodge, J., Huang, L.L., and Jacques, P. Aging in the eye lens:Roles for proteolysis and nutrition in formation of cataract. AGE (1991) 14:65-71.

32. Taylor, A., Jacques, P., Nadler, D., Morrow, F., Sulsky, S.I., and Shepard, D. Relationship between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humor, and plasma. Curr. Eye Res. (1991) 10:751-759.

31. Taylor, A., Berger, J. Reddan, J., and Zuliani, A. Effects of aging in vitro on intracellular proteolysis in cultured rabbit lens epithelial cells in the presence and absence of serum. In Vitro Cell. Develop. Biol. (1991) 27A:287-292.

30. Jahngen-Hodge, J.H., Laxman, E., Zuliani, A., and Taylor, A. Evidence for ATP ubiquitin-dependent degradation of proteins in cultured bovine lens epithelial cells. Exp. Eye Res. (1991) 52:341-347.

29. Lipman, R.D., Cyr, D.E., David, L., and Taylor, A. Calpain in cultured bovine lens epithelial cells. Curr. Eye Res. (1991) 10:11-17.

28. Burley, S.K., David, P.R., Taylor, A., and Lipscomb, W.N. Three-dimensional structure of bovine lens leucine aminopeptidase at 3.0 Å resolution. Proc. Natl. Acad. Sci. USA (1990) 87:6878-6882.

27. Murakami, K., Jahngen, J.H., Lin, S., Davies, K.J.A., and Taylor, A. Lens proteasome shows enhanced rates of degradation of hydroxyl radical modified alpha-crystallin. Free Radic. Biol. Med. (1990) 8:217-222.

26. Meydani, S.N., Lipman, R., Blumberg, J.B., and Taylor, A. Dietary energy restriction decreases ex-vivo spleen prostaglandin E2 synthesis in Emory mice. J. Nutr. (1990) 120:112-115.

25. Jahngen, J.H., Lipman, R.D., Eisenhauer, D.A., Jahngen, E.G.E., Jr., and Taylor, A. Aging and cellular maturation cause changes in ubiquitin-eye lens protein conjugates. Arch. Biochem. Biophys. (1990) 276:32-37.

24. Taylor, A. Associations between nutrition and eye lens cataract. Nutr. Rev. (1989) 47:225-234.

23. Berger, J., Shepard, D., Morrow, F., and Taylor, A. Relationship between dietary intake and tissue levels of reduced and total vitamin C in the non-scorbutic guinea pig. J. Nutr. (1989) 119:734-740.

22. Taylor, A., Zuliani, A.M., Hopkins, R.E., Dallal, G.E., Treglia, P., Kuck, J.F.R., and Kuck, K.A. Moderate caloric restriction delays cataract formation in the Emory mouse. FASEB J. (1989) 3:1741-1746.

21. Berger, J., Eisenhauer, D., and Taylor, A. Intracellular protein degradation in cultured bovine lens epithelial cells. In Vitro Cell. Dev. Biol. (1988) 24:990-994.

20. Murakami, K., Jahngen, J., and Taylor, A. Properties of the ubiquitin conjugation system from bovine eye lens. Curr. Eye Res. (1988) 7:831-835.

19. Berger, J., Shepard, D., Morrow, F., Sadowski, J., Haire, T., and Taylor, A. Reduced and total ascorbate in guinea pig eye tissues in response to dietary intake. Curr. Eye Res., (1988) 7:681-686.

18. Eisenhauer, D.A., Berger, J.J., Peltier, C.Z., and Taylor, A. Protease activities in cultured beef lens epithelial cells peak and then decline upon progressive passage. Exp. Eye Res. (1988) 46:579-590.

17. Lipman, R., and Taylor, A. The in vitro replicative potential and cellular morphology of human lens epithelial cells derived from different aged donors. Curr. Eye Res. (1987) 6:1453-1457.

16. Taylor, A., and Davies, K.J.A. Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens. Free Radic. Biol. Med. (1987) 3:371-377.

15. Blondin, J., and Taylor, A. Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: ascorbate can delay this damage. Mech. Ageing Dev. (1987) 41:39-46.

14. Blondin, J., Baragi, V.J., Schwartz, E., Sadowski, J., and Taylor, A. Delay of UV-induced eye lens protein damage in guinea pigs by dietary ascorbate. Free Radic. Biol. Med. (1986) 2:275-281.

13. Jahngen, J.H., Haas, A.L., Ciechanover, A., Blondin, J., Eisenhauer, D., and Taylor, A. The eye lens has an active ubiquitin protein conjugation system. J. Biol. Chem. (1986) 261:13760-13767.

12. Jahngen, J.H., Eisenhauer, D.A., and Taylor, A. Lens proteins are substrates for the reticulocyte ubiquitin conjugation system. Curr. Eye Res. (1986) 5:725-733.

11. Oettgen, H.C., and Taylor, A. Purification and characterization of leucine aminopeptidase from hog lens. Analyt. Biochem. (1985) 146:238-245.

10. Taylor, A., Volz, K., Lipscomb, W.N., and Takemoto, L. Leucine aminopeptidase from bovine lens and hog kidney: Comparison using immunological techniques, electron microscopy and x-ray diffraction. J. Biol. Chem. (1984) 259:14757-14761.

9. Taylor, A., Surgenor, T., Thomson, D.K.R., Graham, R.J., and Oettgen, H.C. Comparison of (concentration and amino acid sequence homology between) leucine aminopeptidase in human lens, beef lens, beef kidney, hog lens, and hog kidney. Exp. Eye Res. (1984) 38:217-229.

8. Taylor, A., Brown, M.J., Daims, M.A., and Cohen, J. Localization of leucine aminopeptidase in hog lenses using immunofluorescence and activity assays. Invest. Ophthalmol. Vis. Sci. (1983) 24:1172-1181.

7. Taylor, A., Daims, M.A., Lee, J., and Surgenor, T. Identification and quantification of inactive leucine aminopeptidase in aged normal and cataractous human lenses and ability of bovine lens LAP to cleave bovine crystallins. Curr. Eye Res. (1982) 2:47-56.

6. Ricci, J., Bousvaros, A., and Taylor, A. The crystal and molecular structure of bestatin. Interaction of this transition state analog with leucine aminopeptidase. J. Org. Chem. (1982) 46:3063-3065.

5. Taylor, A., Sawan, S., and James, T. On the binding of leucyl-o-sulfonic acid in leucine aminopeptidase. Interaction between this substrate analog and the activation site metal-viewed by NMR. J. Biol. Chem. (1982) 257:11571-11576.

4. Taylor, A., Tisdell, F.E., and Carpenter, F.H. Leucine aminopeptidase (bovine lens): synthesis and kinetic properties of ortho, meta, and para substituted leucyl-anilides. Arch. Biochem. Biophys. (1981) 210:90-97.

3. Taylor, A., Carpenter, F.H., and Wlodawer, A. Leucine aminopeptidase (bovine lens): an electron microscopic study. J. Ultrastruct. Res. (1979) 68:92-100.

2. Jurnak, F., Rich, A., von Loon Klaassen, L., Bloemendal, H., Taylor, A., and Carpenter, F.H. Preliminary x-ray study of leucine aminopeptidase (bovine lens): an oligomeric metalloenzyme. J. Mol. Biol. (1977) 112:149-153.

1. Taylor, A. The synthesis and analysis of an antihypercholesterolemic polysaccaride. Ph.D. thesis, Rutgers University, 1973.