Speaker: Misha E. Kilmer Affiliation: Tufts University, Dept. of Mathematics Title: Krylov Subspace Recycling in Diffuse Optical Tomography Abstract: The need to solve a sequence of large-scale linear systems involving matrices whose characteristics vary slowly from one subsequent system to the next arises frequently in image reconstruction problems. In tomography applications (electrical impedance or diffuse optical tomography), for example, one often needs a nonlinear forward model in the form of a discretized partial differential equation (PDE) to describe the relationship between the desired quantity (e.g. a 3D image of the diffusion of light in tissue) and the measured data. To find the desired image requires the solution of a nonlinear optimization problem for the unknown voxel values in the image, which in turn requires the solution of multiple linear systems (the discretized PDEs) -- one or more such systems in each iteration of the optimization algorithm. In this talk, we analyze matrix characteristics and techniques for reducing the computational complexity of the sequence of systems arising in tomography applications. In particular, we derive strategies for recycling Krylov subspace information that exploit properties of the application and the nonlinear optimization algorithm to significantly reduce the total number of iterations over all linear systems. Although we focus on a particular application, our approach is applicable generally to problems where sequences of linear systems must be solved. Examples illustrate the promise of our approach in reducing the overall computational complexity of nonlinear image reconstruction problems.