Model reduction for large-scale applications in probabilistic analysis and inverse problems Karen Willcox Department of Aeronautics and Astronautics Massachusetts Institute of Technology Model reduction entails the systematic generation of cost-efficient representations of large-scale systems that result, for example, from discretization of partial differential equations. Considerable progress in model reduction methodologies for large-scale systems has seen successful application to many fields, such as computational fluid dynamics, structural dynamics, atmospheric modeling, and circuit design. This talk presents recent developments in methodology to address the challenges of deriving reduced models that span a wide range of parametric inputs. Our scalable algorithm for sampling high-dimensional input spaces makes tractable large-scale probabilistic analysis and inverse problem applications. The methodology is demonstrated for inverse problems in contaminant transport, reacting flow, and porous media flow.